The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4+ T cells, contributes to IBD. Th17 cells promot...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8813558 |
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| author | Jun-bin Yan Min-min Luo Zhi-yun Chen Bei-hui He |
| author_facet | Jun-bin Yan Min-min Luo Zhi-yun Chen Bei-hui He |
| author_sort | Jun-bin Yan |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4+ T cells, contributes to IBD. Th17 cells promote tissue inflammation, and Treg cells suppress autoimmunity in IBD. Therefore, Th17/Treg cell balance is crucial. Some regulatory factors affecting the production and maintenance of these cells are also important for the proper regulation of the Th17/Treg balance; these factors include T cell receptor (TCR) signaling, costimulatory signals, cytokine signaling, bile acid metabolites, and the intestinal microbiota. This article focuses on our understanding of the function and role of the balance between Th17/Treg cells in IBD and these regulatory factors and their clinical significance in IBD. |
| format | Article |
| id | doaj-art-c9476f0098aa4c61b4abff234489edbe |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c9476f0098aa4c61b4abff234489edbe2025-08-20T03:23:58ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/88135588813558The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel DiseaseJun-bin Yan0Min-min Luo1Zhi-yun Chen2Bei-hui He3The Second Central Laboratory, Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaThe Second Central Laboratory, Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaThe Second Central Laboratory, Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaThe Second Central Laboratory, Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaInflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4+ T cells, contributes to IBD. Th17 cells promote tissue inflammation, and Treg cells suppress autoimmunity in IBD. Therefore, Th17/Treg cell balance is crucial. Some regulatory factors affecting the production and maintenance of these cells are also important for the proper regulation of the Th17/Treg balance; these factors include T cell receptor (TCR) signaling, costimulatory signals, cytokine signaling, bile acid metabolites, and the intestinal microbiota. This article focuses on our understanding of the function and role of the balance between Th17/Treg cells in IBD and these regulatory factors and their clinical significance in IBD.http://dx.doi.org/10.1155/2020/8813558 |
| spellingShingle | Jun-bin Yan Min-min Luo Zhi-yun Chen Bei-hui He The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease Journal of Immunology Research |
| title | The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease |
| title_full | The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease |
| title_fullStr | The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease |
| title_full_unstemmed | The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease |
| title_short | The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease |
| title_sort | function and role of the th17 treg cell balance in inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2020/8813558 |
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