Frequently Ill Child Syndrome
The efficacy of cycloferon use in the treatment of frequently ill children (FIC) was estimated by the dynamics of the blood plasma proteomic profile. A group of FIC at the age of 4 to 10 years were observed. Cycloferon was administered according to the standard schemes. The results were analysed by...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/452 |
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| _version_ | 1849389287258193920 |
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| author | M. G. Romantsov I. Yu. Melnikova I. V. Sarvilina |
| author_facet | M. G. Romantsov I. Yu. Melnikova I. V. Sarvilina |
| author_sort | M. G. Romantsov |
| collection | DOAJ |
| description | The efficacy of cycloferon use in the treatment of frequently ill children (FIC) was estimated by the dynamics of the blood plasma proteomic profile. A group of FIC at the age of 4 to 10 years were observed. Cycloferon was administered according to the standard schemes. The results were analysed by the computer programme complex, including the anamnesis, clinical symptoms, infection index, findings of the electrophoretic and mass-spectrometric analyses of the blood plasma before and after the drug use. The intensity indices of the Rho and Ras proteins, the signal pathways, in the blood proteomic profile proved to be sensitive and specific parameters for estimating the regimens of the therapy and prophylaxis of respiratory tract infection in FIC. The epidemiologic efficacy of cycloferon, as an agent of nonspecific immunoprophylaxis for FIC during seasonal prevalence of respiratory tract infection and influenza cases was shown. |
| format | Article |
| id | doaj-art-c9471c71b6204b47b3b401ca4744cc4e |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-c9471c71b6204b47b3b401ca4744cc4e2025-08-20T03:42:01ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01579-10816451Frequently Ill Child SyndromeM. G. Romantsov0I. Yu. MelnikovaI. V. Sarvilina1I. I. Mechnikov North-Western Medical UniversitySouth Scientific Centre, Russian Academy of SciencesThe efficacy of cycloferon use in the treatment of frequently ill children (FIC) was estimated by the dynamics of the blood plasma proteomic profile. A group of FIC at the age of 4 to 10 years were observed. Cycloferon was administered according to the standard schemes. The results were analysed by the computer programme complex, including the anamnesis, clinical symptoms, infection index, findings of the electrophoretic and mass-spectrometric analyses of the blood plasma before and after the drug use. The intensity indices of the Rho and Ras proteins, the signal pathways, in the blood proteomic profile proved to be sensitive and specific parameters for estimating the regimens of the therapy and prophylaxis of respiratory tract infection in FIC. The epidemiologic efficacy of cycloferon, as an agent of nonspecific immunoprophylaxis for FIC during seasonal prevalence of respiratory tract infection and influenza cases was shown.https://www.antibiotics-chemotherapy.ru/jour/article/view/452frequently ill childrencycloferontreatmentprophylaxis |
| spellingShingle | M. G. Romantsov I. Yu. Melnikova I. V. Sarvilina Frequently Ill Child Syndrome Антибиотики и Химиотерапия frequently ill children cycloferon treatment prophylaxis |
| title | Frequently Ill Child Syndrome |
| title_full | Frequently Ill Child Syndrome |
| title_fullStr | Frequently Ill Child Syndrome |
| title_full_unstemmed | Frequently Ill Child Syndrome |
| title_short | Frequently Ill Child Syndrome |
| title_sort | frequently ill child syndrome |
| topic | frequently ill children cycloferon treatment prophylaxis |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/452 |
| work_keys_str_mv | AT mgromantsov frequentlyillchildsyndrome AT iyumelnikova frequentlyillchildsyndrome AT ivsarvilina frequentlyillchildsyndrome |