Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial
Objective: To evaluate the efficacy of Sanhua essential oil inhalation as aromatherapy in patients with breast cancer-related depression. Methods: In total, 144 patients with breast cancer-related depression who underwent postoperative chemotherapy were recruited. The participants in the control gro...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Journal of Traditional Chinese Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754825000535 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849420885145944064 |
|---|---|
| author | Xiaofei Li Zehui Xu Mengting Dong Yuelian Wang Xinyue Zhou Ke Jiang Jiayu Sheng |
| author_facet | Xiaofei Li Zehui Xu Mengting Dong Yuelian Wang Xinyue Zhou Ke Jiang Jiayu Sheng |
| author_sort | Xiaofei Li |
| collection | DOAJ |
| description | Objective: To evaluate the efficacy of Sanhua essential oil inhalation as aromatherapy in patients with breast cancer-related depression. Methods: In total, 144 patients with breast cancer-related depression who underwent postoperative chemotherapy were recruited. The participants in the control group (n = 52) were offered a placebo (sunflower oil) daily, whereas those in the essential oil group (n = 52) were administered Sanhua essential oil. This study evaluated depression improvement, Hamilton Depression Scale score, scores of symptoms in traditional Chinese medicine (TCM), Pittsburgh Sleepiness Quotient Index score, incidence of nausea and vomiting, and signal changes on functional magnetic resonance imaging. Results: Depression improved by 48.1% and 21.2% in the essential oil and control groups, respectively (P = .010). The Hamilton Depression Scale score (P = .017), scores for symptoms in TCM (P = .002), and the incidence of nausea and vomiting in the acute and delayed phases were lower in the essential oil group than in the control group (nausea in the acute phase, P = .017; nausea in the delayed phase, P = .039; vomiting in the acute phase, P = .008; vomiting in the delayed phase, P = .081). The Pittsburgh Sleepiness Quotient Index score was lower in the essential oil group than in the control group (P = .005). Significant differences existed between the two groups in the left superior parietal gyrus, right precuneus, left dorsolateral superior frontal gyrus, and right precentral gyrus according to functional connectivity on functional magnetic resonance imaging. Conclusion: Inhalation of Sanhua essential oil alleviated depression in patients undergoing chemotherapy for breast cancer, improved sleep quality, relieved TCM symptoms, reduced nausea and vomiting, and regulated activities in the brain regions. |
| format | Article |
| id | doaj-art-c93cb7d79aaf4acfb1175c2c779a574b |
| institution | Kabale University |
| issn | 2095-7548 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj-art-c93cb7d79aaf4acfb1175c2c779a574b2025-08-20T03:31:37ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482025-07-0112334835710.1016/j.jtcms.2025.05.003Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trialXiaofei Li0Zehui Xu1Mengting Dong2Yuelian Wang3Xinyue Zhou4Ke Jiang5Jiayu Sheng6Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaCorresponding author.; Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, ChinaObjective: To evaluate the efficacy of Sanhua essential oil inhalation as aromatherapy in patients with breast cancer-related depression. Methods: In total, 144 patients with breast cancer-related depression who underwent postoperative chemotherapy were recruited. The participants in the control group (n = 52) were offered a placebo (sunflower oil) daily, whereas those in the essential oil group (n = 52) were administered Sanhua essential oil. This study evaluated depression improvement, Hamilton Depression Scale score, scores of symptoms in traditional Chinese medicine (TCM), Pittsburgh Sleepiness Quotient Index score, incidence of nausea and vomiting, and signal changes on functional magnetic resonance imaging. Results: Depression improved by 48.1% and 21.2% in the essential oil and control groups, respectively (P = .010). The Hamilton Depression Scale score (P = .017), scores for symptoms in TCM (P = .002), and the incidence of nausea and vomiting in the acute and delayed phases were lower in the essential oil group than in the control group (nausea in the acute phase, P = .017; nausea in the delayed phase, P = .039; vomiting in the acute phase, P = .008; vomiting in the delayed phase, P = .081). The Pittsburgh Sleepiness Quotient Index score was lower in the essential oil group than in the control group (P = .005). Significant differences existed between the two groups in the left superior parietal gyrus, right precuneus, left dorsolateral superior frontal gyrus, and right precentral gyrus according to functional connectivity on functional magnetic resonance imaging. Conclusion: Inhalation of Sanhua essential oil alleviated depression in patients undergoing chemotherapy for breast cancer, improved sleep quality, relieved TCM symptoms, reduced nausea and vomiting, and regulated activities in the brain regions.http://www.sciencedirect.com/science/article/pii/S2095754825000535Breast cancerChemotherapyCancer-related depressionAromatherapyEssential oilInhalation |
| spellingShingle | Xiaofei Li Zehui Xu Mengting Dong Yuelian Wang Xinyue Zhou Ke Jiang Jiayu Sheng Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial Journal of Traditional Chinese Medical Sciences Breast cancer Chemotherapy Cancer-related depression Aromatherapy Essential oil Inhalation |
| title | Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial |
| title_full | Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial |
| title_fullStr | Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial |
| title_full_unstemmed | Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial |
| title_short | Efficacy of Sanhua essential oil inhalation in patients with breast cancer-related depression undergoing chemotherapy: A randomized, single-masked, placebo-controlled clinical trial |
| title_sort | efficacy of sanhua essential oil inhalation in patients with breast cancer related depression undergoing chemotherapy a randomized single masked placebo controlled clinical trial |
| topic | Breast cancer Chemotherapy Cancer-related depression Aromatherapy Essential oil Inhalation |
| url | http://www.sciencedirect.com/science/article/pii/S2095754825000535 |
| work_keys_str_mv | AT xiaofeili efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial AT zehuixu efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial AT mengtingdong efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial AT yuelianwang efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial AT xinyuezhou efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial AT kejiang efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial AT jiayusheng efficacyofsanhuaessentialoilinhalationinpatientswithbreastcancerrelateddepressionundergoingchemotherapyarandomizedsinglemaskedplacebocontrolledclinicaltrial |