Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis
ObjectiveThis study aimed to evaluate the effectiveness of non-invasive brain stimulation (NIBS) in improving cognitive function and activities of daily living (ADL) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). It also sought to explore the moderating effec...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1585901/full |
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| author | Hui Ding Chen Wei Jiwei Chen Fen Yu Xing Wang Yuanwen Zhang |
| author_facet | Hui Ding Chen Wei Jiwei Chen Fen Yu Xing Wang Yuanwen Zhang |
| author_sort | Hui Ding |
| collection | DOAJ |
| description | ObjectiveThis study aimed to evaluate the effectiveness of non-invasive brain stimulation (NIBS) in improving cognitive function and activities of daily living (ADL) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). It also sought to explore the moderating effects of age, intervention duration, latency period, and stimulation site.MethodsA systematic search of seven databases was conducted to identify randomized controlled trials (RCTs) published up to August 2024. Meta-analyses and publication bias assessments were performed using RevMan 5.4.1 and Stata 17.0. Methodological quality was evaluated with the PEDro scale, and the certainty of evidence was assessed using GRADEpro.ResultsA total of eight RCTs involving 607 participants were included. The pooled results indicated that NIBS significantly improved cognitive function (standardized mean difference (SMD = 1.03, p < 0.00001) and ADL (SMD = 1.77, p < 0.00001). The subgroup analyses showed greater cognitive improvements in patients aged below 50 years, with intervention durations of ≤20 days and stimulation applied at the yin–yang poles. In contrast, improvements in daily activities were more pronounced in patients aged over 50 years under similar intervention conditions.DiscussionThe included studies were of moderate-to-high quality (mean PEDro score = 6.3). The major limitations included inadequate blinding and incomplete allocation concealment. The heterogeneity observed was mainly attributable to patient age, stimulation site, and intervention duration. No significant publication bias was detected. Overall, NIBS demonstrated moderate-quality evidence in enhancing cognitive function and daily activity performance, with individual characteristics moderating its effects.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024598815. |
| format | Article |
| id | doaj-art-c93a14d77fd84910aaa8658d3a732326 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-c93a14d77fd84910aaa8658d3a7323262025-08-20T03:41:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.15859011585901Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysisHui Ding0Chen Wei1Jiwei Chen2Fen Yu3Xing Wang4Yuanwen Zhang5School of Physical Education, Shanghai Normal University, Shanghai, ChinaSchool of Physical Education, Shenyang Normal University, Shenyang, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai Normal University, Shanghai, ChinaObjectiveThis study aimed to evaluate the effectiveness of non-invasive brain stimulation (NIBS) in improving cognitive function and activities of daily living (ADL) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). It also sought to explore the moderating effects of age, intervention duration, latency period, and stimulation site.MethodsA systematic search of seven databases was conducted to identify randomized controlled trials (RCTs) published up to August 2024. Meta-analyses and publication bias assessments were performed using RevMan 5.4.1 and Stata 17.0. Methodological quality was evaluated with the PEDro scale, and the certainty of evidence was assessed using GRADEpro.ResultsA total of eight RCTs involving 607 participants were included. The pooled results indicated that NIBS significantly improved cognitive function (standardized mean difference (SMD = 1.03, p < 0.00001) and ADL (SMD = 1.77, p < 0.00001). The subgroup analyses showed greater cognitive improvements in patients aged below 50 years, with intervention durations of ≤20 days and stimulation applied at the yin–yang poles. In contrast, improvements in daily activities were more pronounced in patients aged over 50 years under similar intervention conditions.DiscussionThe included studies were of moderate-to-high quality (mean PEDro score = 6.3). The major limitations included inadequate blinding and incomplete allocation concealment. The heterogeneity observed was mainly attributable to patient age, stimulation site, and intervention duration. No significant publication bias was detected. Overall, NIBS demonstrated moderate-quality evidence in enhancing cognitive function and daily activity performance, with individual characteristics moderating its effects.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024598815.https://www.frontiersin.org/articles/10.3389/fneur.2025.1585901/fullnon-invasive brain stimulationcarbon monoxide poisoningcognitive functionactivities of daily livingsystematic reviewmeta-analysis |
| spellingShingle | Hui Ding Chen Wei Jiwei Chen Fen Yu Xing Wang Yuanwen Zhang Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis Frontiers in Neurology non-invasive brain stimulation carbon monoxide poisoning cognitive function activities of daily living systematic review meta-analysis |
| title | Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis |
| title_full | Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis |
| title_fullStr | Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis |
| title_short | Effect of non-invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning: a systematic review and meta-analysis |
| title_sort | effect of non invasive brain stimulation on cognitive function and activities of daily living in patients with carbon monoxide poisoning a systematic review and meta analysis |
| topic | non-invasive brain stimulation carbon monoxide poisoning cognitive function activities of daily living systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1585901/full |
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