Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report
Systemic lupus erythematosus (SLE) is an autoimmune, chronic, and heterogenous disease with organ damage resulting from immune complex deposition and inflammatory infiltrates. Antimalarial drugs, such as hydroxychloroquine (HCQ), are cornerstone immunomodulators for the treatment of SLE. Rarely, HCQ...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2022/6503453 |
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| author | Ahmad Ramahi Amer Heider J. Michelle Kahlenberg |
| author_facet | Ahmad Ramahi Amer Heider J. Michelle Kahlenberg |
| author_sort | Ahmad Ramahi |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an autoimmune, chronic, and heterogenous disease with organ damage resulting from immune complex deposition and inflammatory infiltrates. Antimalarial drugs, such as hydroxychloroquine (HCQ), are cornerstone immunomodulators for the treatment of SLE. Rarely, HCQ toxicity can occur, leading to devastating outcomes. We report a case of a patient with SLE on HCQ who presented with a rapid onset of large pericardial effusion and a dramatically decreased left ventricular ejection fraction. Endomyocardial biopsy was positive for curvilinear bodies, confirming the diagnosis of hydroxychloroquine cardiotoxicity. Hydroxychloroquine cardiomyopathy is a rare but life-threatening medication side effect. It is important to consider it in any patient taking the medication who presents with a new onset or worsening symptoms of heart failure. |
| format | Article |
| id | doaj-art-c92ee32963ba4f278c8e1d94859ab77d |
| institution | OA Journals |
| issn | 2090-6897 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-c92ee32963ba4f278c8e1d94859ab77d2025-08-20T02:19:42ZengWileyCase Reports in Rheumatology2090-68972022-01-01202210.1155/2022/6503453Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case ReportAhmad Ramahi0Amer Heider1J. Michelle Kahlenberg2Division of RheumatologyDepartment of PathologyDivision of RheumatologySystemic lupus erythematosus (SLE) is an autoimmune, chronic, and heterogenous disease with organ damage resulting from immune complex deposition and inflammatory infiltrates. Antimalarial drugs, such as hydroxychloroquine (HCQ), are cornerstone immunomodulators for the treatment of SLE. Rarely, HCQ toxicity can occur, leading to devastating outcomes. We report a case of a patient with SLE on HCQ who presented with a rapid onset of large pericardial effusion and a dramatically decreased left ventricular ejection fraction. Endomyocardial biopsy was positive for curvilinear bodies, confirming the diagnosis of hydroxychloroquine cardiotoxicity. Hydroxychloroquine cardiomyopathy is a rare but life-threatening medication side effect. It is important to consider it in any patient taking the medication who presents with a new onset or worsening symptoms of heart failure.http://dx.doi.org/10.1155/2022/6503453 |
| spellingShingle | Ahmad Ramahi Amer Heider J. Michelle Kahlenberg Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report Case Reports in Rheumatology |
| title | Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report |
| title_full | Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report |
| title_fullStr | Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report |
| title_full_unstemmed | Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report |
| title_short | Rapid Onset and Resolution of Hydroxychloroquine Cardiomyopathy: A Case Report |
| title_sort | rapid onset and resolution of hydroxychloroquine cardiomyopathy a case report |
| url | http://dx.doi.org/10.1155/2022/6503453 |
| work_keys_str_mv | AT ahmadramahi rapidonsetandresolutionofhydroxychloroquinecardiomyopathyacasereport AT amerheider rapidonsetandresolutionofhydroxychloroquinecardiomyopathyacasereport AT jmichellekahlenberg rapidonsetandresolutionofhydroxychloroquinecardiomyopathyacasereport |