Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development

Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development

Abstract Background The monkeypox virus (MPXV) has raised global health concerns due to its widespread transmission. This study evaluated the MPXV immunogenic antigens and the impact of vaccinia virus (VACV) vaccination and MPXV infection on cross-reactive antibody responses to conserved proteins fr...

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Main Authors: Jing Liu, Xun Wang, Yiting Zhang, Changyi Liu, Meng Zhang, Chen Li, Peiling Liu, Shanshan Li, Kaifeng Wei, Yiming Cai, Hongjie Yu, Zhiliang Hu, Pengfei Wang, Yanliang Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Infectious Diseases of Poverty
Subjects:
Monkeypox
Cross-reactive antibody response
Immunogenicity
Entry fusion complex
Online Access:https://doi.org/10.1186/s40249-025-01280-1
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