A proof-of-concept study to investigate the radiolabelling of human mesenchymal and hematopoietic stem cells with [89Zr]Zr-Df-Bz-NCS

A proof-of-concept study to investigate the radiolabelling of human mesenchymal and hematopoietic stem cells with [89Zr]Zr-Df-Bz-NCS

Abstract Background The transplantation of hematopoietic stem and progenitor cells (HSPCs) or mesenchymal stromal/stem cells (MSCs) for the treatment of a wide variety of diseases has been studied extensively. A challenge with cell-based therapies is that migration to and retention at the target sit...

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Bibliographic Details
Main Authors: Maryke Kahts, Juanita Mellet, Chrisna Durandt, Kinosha Moodley, Beverley Summers, Thomas Ebenhan, Jan Rijn Zeevaart, Omer Aras, Michael S. Pepper
Format: Article
Language:English
Published: SpringerOpen 2024-11-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Mesenchymal stem cells (MSCs)
Hematopoietic stem and progenitor cells (HSPCs)
Cell labelling
In vivo cell tracking
Zirconium-89
Positron emission tomography
Online Access:https://doi.org/10.1186/s41181-024-00311-w
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