Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives
Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for bone regeneration, making electrical materials a promising therapy. This review provides a comprehensive overview of the role of...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411209 |
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| author | Yubin Yao Xi Cui Shenglong Ding Ketao Wang Mingzhu Zhang |
| author_facet | Yubin Yao Xi Cui Shenglong Ding Ketao Wang Mingzhu Zhang |
| author_sort | Yubin Yao |
| collection | DOAJ |
| description | Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for bone regeneration, making electrical materials a promising therapy. This review provides a comprehensive overview of the role of bioelectric signals in bone and cartilage cells, alongside recent advancements in electrical biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, and zwitterionic hydrogels. It further investigates the impact of these electrical biomaterials on bone and cartilage regeneration, as well as the applications of both endogenous and exogenous electrical stimulation (ES) and the mechanisms underlying ES‐induced cellular and molecular responses. Finally, the review underscores future directions for ES systems in tissue engineering, emphasizing the critical importance of integrating structural integrity, mechanical properties, and electrical signal delivery into intelligent implantable scaffolds. |
| format | Article |
| id | doaj-art-c92aec6d046749cabea325a6b82ca823 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-c92aec6d046749cabea325a6b82ca8232025-08-20T03:27:10ZengWileyAdvanced Science2198-38442025-06-011224n/an/a10.1002/advs.202411209Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and PerspectivesYubin Yao0Xi Cui1Shenglong Ding2Ketao Wang3Mingzhu Zhang4Department of Foot and Ankle Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaDepartment of Foot and Ankle Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaDepartment of Foot and Ankle Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaDepartment of Foot and Ankle Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaDepartment of Foot and Ankle Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaAbstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for bone regeneration, making electrical materials a promising therapy. This review provides a comprehensive overview of the role of bioelectric signals in bone and cartilage cells, alongside recent advancements in electrical biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, and zwitterionic hydrogels. It further investigates the impact of these electrical biomaterials on bone and cartilage regeneration, as well as the applications of both endogenous and exogenous electrical stimulation (ES) and the mechanisms underlying ES‐induced cellular and molecular responses. Finally, the review underscores future directions for ES systems in tissue engineering, emphasizing the critical importance of integrating structural integrity, mechanical properties, and electrical signal delivery into intelligent implantable scaffolds.https://doi.org/10.1002/advs.202411209electrical biomaterialselectrical stimulationendogenous electric fieldsnanogeneratorspiezoelectric materials |
| spellingShingle | Yubin Yao Xi Cui Shenglong Ding Ketao Wang Mingzhu Zhang Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives Advanced Science electrical biomaterials electrical stimulation endogenous electric fields nanogenerators piezoelectric materials |
| title | Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives |
| title_full | Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives |
| title_fullStr | Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives |
| title_full_unstemmed | Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives |
| title_short | Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives |
| title_sort | advances in electrical materials for bone and cartilage regeneration developments challenges and perspectives |
| topic | electrical biomaterials electrical stimulation endogenous electric fields nanogenerators piezoelectric materials |
| url | https://doi.org/10.1002/advs.202411209 |
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