Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth
Novel composite hydrogels of poly(acrylamide) (PAAm) and starch, at different ratios, were studied as potential platforms for controlled release of amoxicillin. The composite hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-di...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/5860487 |
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| author | Ana V. Torres-Figueroa Cinthia J. Pérez-Martínez Teresa del Castillo-Castro Enrique Bolado-Martínez María A. G. Corella-Madueño Alejandro M. García-Alegría Tania E. Lara-Ceniceros Lorena Armenta-Villegas |
| author_facet | Ana V. Torres-Figueroa Cinthia J. Pérez-Martínez Teresa del Castillo-Castro Enrique Bolado-Martínez María A. G. Corella-Madueño Alejandro M. García-Alegría Tania E. Lara-Ceniceros Lorena Armenta-Villegas |
| author_sort | Ana V. Torres-Figueroa |
| collection | DOAJ |
| description | Novel composite hydrogels of poly(acrylamide) (PAAm) and starch, at different ratios, were studied as potential platforms for controlled release of amoxicillin. The composite hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and swelling kinetic measurements. The morphology analysis revealed the presence of starch granules well embedded within the PAAm network. The increase in starch content increased the rate of water uptake and the swelling degree at equilibrium. The amoxicillin release kinetics was sensitive to pH and temperature conditions. The in vitro bacterial growth inhibition of antibiotic-loaded hydrogels was tested though disc diffusion assays with Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, and a carbapenemase producer Pseudomonas aeruginosa strain. The optimal release profile at physiological conditions and the powerful bacteria growth inhibition effects of amoxicillin-loaded hydrogels evidenced its potential for biomedical applications, particularly in oral administration and the local treatment of bacterial infections. |
| format | Article |
| id | doaj-art-c91d81b319b24245a48205595ed07799 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c91d81b319b24245a48205595ed077992025-02-03T06:43:31ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/58604875860487Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial GrowthAna V. Torres-Figueroa0Cinthia J. Pérez-Martínez1Teresa del Castillo-Castro2Enrique Bolado-Martínez3María A. G. Corella-Madueño4Alejandro M. García-Alegría5Tania E. Lara-Ceniceros6Lorena Armenta-Villegas7Departamento de Ciencias Químico Biológicas, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoDepartamento de Investigación en Polímeros y Materiales, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoAdvanced Functional Materials and Nanotechnology Group, Centro de Investigación en Materiales Avanzados S. C. (CIMAV-Unidad Monterrey), CP 66628, Apodaca, Nuevo León, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, CP 83000, Hermosillo, Sonora, MexicoNovel composite hydrogels of poly(acrylamide) (PAAm) and starch, at different ratios, were studied as potential platforms for controlled release of amoxicillin. The composite hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and swelling kinetic measurements. The morphology analysis revealed the presence of starch granules well embedded within the PAAm network. The increase in starch content increased the rate of water uptake and the swelling degree at equilibrium. The amoxicillin release kinetics was sensitive to pH and temperature conditions. The in vitro bacterial growth inhibition of antibiotic-loaded hydrogels was tested though disc diffusion assays with Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, and a carbapenemase producer Pseudomonas aeruginosa strain. The optimal release profile at physiological conditions and the powerful bacteria growth inhibition effects of amoxicillin-loaded hydrogels evidenced its potential for biomedical applications, particularly in oral administration and the local treatment of bacterial infections.http://dx.doi.org/10.1155/2020/5860487 |
| spellingShingle | Ana V. Torres-Figueroa Cinthia J. Pérez-Martínez Teresa del Castillo-Castro Enrique Bolado-Martínez María A. G. Corella-Madueño Alejandro M. García-Alegría Tania E. Lara-Ceniceros Lorena Armenta-Villegas Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth Journal of Chemistry |
| title | Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth |
| title_full | Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth |
| title_fullStr | Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth |
| title_full_unstemmed | Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth |
| title_short | Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth |
| title_sort | composite hydrogel of poly acrylamide and starch as potential system for controlled release of amoxicillin and inhibition of bacterial growth |
| url | http://dx.doi.org/10.1155/2020/5860487 |
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