Delayed atorvastatin delivery promotes recovery after experimental spinal cord injury

Delayed atorvastatin delivery promotes recovery after experimental spinal cord injury

Spinal cord injury (SCI) significantly alters gene expression, potentially impeding functional recovery. This study investigated the effects of atorvastatin, a widely prescribed cholesterol-lowering drug, on gene expression and functional recovery in a chronic murine SCI model. Female C57BL/6J mice...

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Bibliographic Details
Main Authors: Samuel C. Buchl, Ha Neui Kim, Benjamin Hur, Whitney L. Simon, Monica R. Langley, Jaeyun Sung, Isobel A. Scarisbrick
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Chronic spinal cord injury
Locomotor recovery
RNA sequencing
Spinal cord transcriptomics
Pathway analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747924002046
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