Research progress on the diagnostic value of fecal calprotectin in colorectal tumors
Fecal Calprotectin (FC), a calcium-binding protein secreted by neutrophils and macrophages and belonging to the S100 protein family, has gained increasing utilization in recent years for the diagnosis and monitoring of intestinal diseases due to its high expression and stability in inflammatory resp...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1626197/full |
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| author | Wei Jing Wei Jing Jiangshan Sun Jiangshan Sun Qingzheng Wu Xiuli Zhang |
| author_facet | Wei Jing Wei Jing Jiangshan Sun Jiangshan Sun Qingzheng Wu Xiuli Zhang |
| author_sort | Wei Jing |
| collection | DOAJ |
| description | Fecal Calprotectin (FC), a calcium-binding protein secreted by neutrophils and macrophages and belonging to the S100 protein family, has gained increasing utilization in recent years for the diagnosis and monitoring of intestinal diseases due to its high expression and stability in inflammatory responses. In the field of colorectal tumors, the diagnostic value of FC has gradually emerged. Within colorectal tumors, colorectal cancer (CRC) is an area of significant research focus. Studies have demonstrated significantly elevated FC levels in patients with CRC, a phenomenon potentially linked to chronic inflammation and immune cell infiltration within the tumor microenvironment. FC exhibits notable advantages in colorectal tumor diagnosis, characterized by high sensitivity and moderate specificity. Emerging research has revealed correlations between FC levels and colorectal tumors staging as well as left-sided versus right-sided tumor localization, with elevated FC levels associated with malignant transformation, local inflammation, and advanced tumor stages (T3 and T4). The diagnostic performance of fecal calprotectin (FC) as a non-invasive marker for colorectal tumors has not yet been established. However, due to its association with inflammation, FC holds promise for playing a more significant role in the screening, staging, and localization of colorectal tumors. |
| format | Article |
| id | doaj-art-c91af83b971943688bc18decccb00e90 |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-c91af83b971943688bc18decccb00e902025-08-20T03:17:24ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16261971626197Research progress on the diagnostic value of fecal calprotectin in colorectal tumorsWei Jing0Wei Jing1Jiangshan Sun2Jiangshan Sun3Qingzheng Wu4Xiuli Zhang5Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaFecal Calprotectin (FC), a calcium-binding protein secreted by neutrophils and macrophages and belonging to the S100 protein family, has gained increasing utilization in recent years for the diagnosis and monitoring of intestinal diseases due to its high expression and stability in inflammatory responses. In the field of colorectal tumors, the diagnostic value of FC has gradually emerged. Within colorectal tumors, colorectal cancer (CRC) is an area of significant research focus. Studies have demonstrated significantly elevated FC levels in patients with CRC, a phenomenon potentially linked to chronic inflammation and immune cell infiltration within the tumor microenvironment. FC exhibits notable advantages in colorectal tumor diagnosis, characterized by high sensitivity and moderate specificity. Emerging research has revealed correlations between FC levels and colorectal tumors staging as well as left-sided versus right-sided tumor localization, with elevated FC levels associated with malignant transformation, local inflammation, and advanced tumor stages (T3 and T4). The diagnostic performance of fecal calprotectin (FC) as a non-invasive marker for colorectal tumors has not yet been established. However, due to its association with inflammation, FC holds promise for playing a more significant role in the screening, staging, and localization of colorectal tumors.https://www.frontiersin.org/articles/10.3389/fmed.2025.1626197/fullfecal calprotectin (FC)colorectal tumorsinflammationdiagnosticnon-invasive biomarkers |
| spellingShingle | Wei Jing Wei Jing Jiangshan Sun Jiangshan Sun Qingzheng Wu Xiuli Zhang Research progress on the diagnostic value of fecal calprotectin in colorectal tumors Frontiers in Medicine fecal calprotectin (FC) colorectal tumors inflammation diagnostic non-invasive biomarkers |
| title | Research progress on the diagnostic value of fecal calprotectin in colorectal tumors |
| title_full | Research progress on the diagnostic value of fecal calprotectin in colorectal tumors |
| title_fullStr | Research progress on the diagnostic value of fecal calprotectin in colorectal tumors |
| title_full_unstemmed | Research progress on the diagnostic value of fecal calprotectin in colorectal tumors |
| title_short | Research progress on the diagnostic value of fecal calprotectin in colorectal tumors |
| title_sort | research progress on the diagnostic value of fecal calprotectin in colorectal tumors |
| topic | fecal calprotectin (FC) colorectal tumors inflammation diagnostic non-invasive biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1626197/full |
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