Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens
Penicillium chrysogenum is a commonly occurring mould in indoor environments and foods, and has gained much attention for its use in the production of the antibiotic penicillin. Phylogenetic analysis of the most important penicillin producing P. chrysogenum isolates revealed the presence of two high...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
|
| Series: | IMA Fungus |
| Subjects: | |
| Online Access: | http://www.ingentaconnect.com/content/ima/imafung/2011/00000002/00000001/art00022 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832570801257185280 |
|---|---|
| author | J. Houbraken J.C. Frisvad R.A. Samson |
| author_facet | J. Houbraken J.C. Frisvad R.A. Samson |
| author_sort | J. Houbraken |
| collection | DOAJ |
| description | Penicillium chrysogenum is a commonly occurring mould in indoor environments and foods, and has gained much attention for its use in the production of the antibiotic penicillin. Phylogenetic analysis of the most important penicillin producing P. chrysogenum isolates revealed the presence of two highly supported clades, and we show here that these two clades represent two species, P. chrysogenum and P. rubens. These species are phenotypically similar, but extrolite analysis shows that P. chrysogenum produces secalonic acid D and F and/or a metabolite related to lumpidin, while P. rubens does not produce these metabolites. Fleming's original penicillin producing strain and the full genome sequenced strain of P. chrysogenum are re-identified as P. rubens. Furthermore, the well-known claim that Alexander Fleming misidentified the original penicillin producing strain as P. rubrum is discussed. |
| format | Article |
| id | doaj-art-c91ac7d0591e4746aa9fa70f19127662 |
| institution | Kabale University |
| issn | 2210-6340 2210-6359 |
| language | English |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | IMA Fungus |
| spelling | doaj-art-c91ac7d0591e4746aa9fa70f191276622025-02-02T14:18:25ZengBMCIMA Fungus2210-63402210-63592011-06-01218795Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubensJ. HoubrakenJ.C. FrisvadR.A. SamsonPenicillium chrysogenum is a commonly occurring mould in indoor environments and foods, and has gained much attention for its use in the production of the antibiotic penicillin. Phylogenetic analysis of the most important penicillin producing P. chrysogenum isolates revealed the presence of two highly supported clades, and we show here that these two clades represent two species, P. chrysogenum and P. rubens. These species are phenotypically similar, but extrolite analysis shows that P. chrysogenum produces secalonic acid D and F and/or a metabolite related to lumpidin, while P. rubens does not produce these metabolites. Fleming's original penicillin producing strain and the full genome sequenced strain of P. chrysogenum are re-identified as P. rubens. Furthermore, the well-known claim that Alexander Fleming misidentified the original penicillin producing strain as P. rubrum is discussed.http://www.ingentaconnect.com/content/ima/imafung/2011/00000002/00000001/art00022FLEMINGINDOOR MYCOLOGYPHYLOGENYTAXONOMY |
| spellingShingle | J. Houbraken J.C. Frisvad R.A. Samson Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens IMA Fungus FLEMING INDOOR MYCOLOGY PHYLOGENY TAXONOMY |
| title | Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens |
| title_full | Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens |
| title_fullStr | Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens |
| title_full_unstemmed | Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens |
| title_short | Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens |
| title_sort | fleming s penicillin producing strain is not penicillium chrysogenum but p rubens |
| topic | FLEMING INDOOR MYCOLOGY PHYLOGENY TAXONOMY |
| url | http://www.ingentaconnect.com/content/ima/imafung/2011/00000002/00000001/art00022 |
| work_keys_str_mv | AT jhoubraken flemingspenicillinproducingstrainisnotpenicilliumchrysogenumbutprubens AT jcfrisvad flemingspenicillinproducingstrainisnotpenicilliumchrysogenumbutprubens AT rasamson flemingspenicillinproducingstrainisnotpenicilliumchrysogenumbutprubens |