Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease
Background. Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections. Conclusion....
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2021/6612710 |
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| _version_ | 1850174195488522240 |
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| author | Yael Kusne Michael Christiansen Christopher Conley Juan Gea-Banacloche Ayan Sen |
| author_facet | Yael Kusne Michael Christiansen Christopher Conley Juan Gea-Banacloche Ayan Sen |
| author_sort | Yael Kusne |
| collection | DOAJ |
| description | Background. Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections. Conclusion. Patients presenting with HLH are critically ill, and rapid diagnosis is key. In adults, the search for the trigger must begin promptly as time to diagnosis effects survival. The underlying trigger in our patients was Histoplasma capsulatum infection, which is rare in the southwestern United States. Prompt diagnosis led to recovery in one patient, while the other did not survive. |
| format | Article |
| id | doaj-art-c918ef4974b047be9f20de06a55a4528 |
| institution | OA Journals |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-c918ef4974b047be9f20de06a55a45282025-08-20T02:19:41ZengWileyCase Reports in Critical Care2090-64202090-64392021-01-01202110.1155/2021/66127106612710Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic DiseaseYael Kusne0Michael Christiansen1Christopher Conley2Juan Gea-Banacloche3Ayan Sen4Department of Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ, USADepartment of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USADepartment of Pathology, Mayo Clinic Arizona, Phoenix, AZ, USADepartment of Infectious Disease, Mayo Clinic Arizona, Phoenix, AZ, USADepartment of Critical Care Medicine, Mayo Clinic Arizona, Phoenix, AZ, USABackground. Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections. Conclusion. Patients presenting with HLH are critically ill, and rapid diagnosis is key. In adults, the search for the trigger must begin promptly as time to diagnosis effects survival. The underlying trigger in our patients was Histoplasma capsulatum infection, which is rare in the southwestern United States. Prompt diagnosis led to recovery in one patient, while the other did not survive.http://dx.doi.org/10.1155/2021/6612710 |
| spellingShingle | Yael Kusne Michael Christiansen Christopher Conley Juan Gea-Banacloche Ayan Sen Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease Case Reports in Critical Care |
| title | Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease |
| title_full | Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease |
| title_fullStr | Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease |
| title_short | Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease |
| title_sort | hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in rheumatologic disease |
| url | http://dx.doi.org/10.1155/2021/6612710 |
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