Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients

Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients

BackgroundDocetaxel is commonly used in breast cancer chemotherapy. The previous drug dose is generally calculated based on body surface area (BSA). However, the metabolism varies greatly among different patients. Docetaxel therapeutic drug monitoring (TDM) helps monitor adverse drug reactions and e...

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Main Authors: Yongzhe Tang, Yamin Liu, Shengying Qin, Cong Huai, Jin Zhang, Weijie Ding, Junwei Fan, Jie Wang, Xiaoqing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Docetaxel
TDM (therapeutic drug monitoring)
AUC (area under the curve)
adverse reactions
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1563506/full
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