Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity
Background: A novel peptide known as Elabela was recently discovered; it functions similarly to apelin and acts through apelin receptors. This research is to compare the characteristics and biological roles of apelin and Elabela in patients with metabolic syndrome who are obese and those who are no...
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College of medicine/ University of Diyala
2025-06-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/1187 |
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| author | Layla Imad Ali Shaimaa Imad Ali Fayhaa M. Khaleel Wasan Saher Hassan Kawther Adeeb Hussein Great Iruoghene Edo |
| author_facet | Layla Imad Ali Shaimaa Imad Ali Fayhaa M. Khaleel Wasan Saher Hassan Kawther Adeeb Hussein Great Iruoghene Edo |
| author_sort | Layla Imad Ali |
| collection | DOAJ |
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Background: A novel peptide known as Elabela was recently discovered; it functions similarly to apelin and acts through apelin receptors. This research is to compare the characteristics and biological roles of apelin and Elabela in patients with metabolic syndrome who are obese and those who are not.
Patients and Methods: A cross-sectional study included 90 participants, ages 20–45, whose samples were collected from Al-Yarmouk-Hospital/Al-Karkh/Baghdad, from April–July/2024. Classified into three groups: group1 was obese metabolic syndrome patients (N=30), group 2 was metabolic syndrome patients without obesity (N=30), and group 3 was control (N=30). Anthropometrics and parameters were assessed for all study groups. Fasting blood glucose levels and lipid profiles were determined using an enzymatic process with spectrophotometric methods, while insulin, apelin, and Elabela were evaluated by enzyme-linked immunosorbent assay.
Results: The result shows a significant difference in Body Mass Index, Waist to Hip Ratio, Lipid profile, FBS, apelin, insulin, and HOMA-IR, while there was no significant difference between the study groups in Elabela levels. In addition, there is a positive correlation between apelin and BMI, FBS, and insulin. apelin levels have a higher diagnostic value for obesity than metabolic syndrome, respectively.
Conclusion: This study suggests that apelin and Elabela are powerful modulators of the metabolism of adipose cell and highlights the crucial role of apelin in MetS in both non-obese and obese MetS, as well as in clinical and biochemical markers associated with obesity.
Keywords: Apelin, APJ, Elabela, Metabolic Syndrome, Obesity.
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| format | Article |
| id | doaj-art-c916ca9036244d59aced193a3cc5d008 |
| institution | Kabale University |
| issn | 2219-9764 2617-8982 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj-art-c916ca9036244d59aced193a3cc5d0082025-08-20T03:50:31ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822025-06-0128210.26505/djm.v28i2.1187Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with ObesityLayla Imad Ali0Shaimaa Imad Ali1Fayhaa M. Khaleel2Wasan Saher Hassan3Kawther Adeeb Hussein4Great Iruoghene Edo5Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.Department of Chemistry, College of science, Al-Nahrain University, Jadriya, Baghdad, Iraq.Department of Chemistry, College of Sciences for Women, University of Baghdad, Baghdad, Iraq.Department of Biochemistry, College of Medicine, University of Diyala, Diyala, Iraq.Department of Chemistry, College of science, Al-Nahrain University, Jadriya, Baghdad, Iraq.Department of Chemistry, Delta State University of Science and Technology, Ozoro, Nigeria. Background: A novel peptide known as Elabela was recently discovered; it functions similarly to apelin and acts through apelin receptors. This research is to compare the characteristics and biological roles of apelin and Elabela in patients with metabolic syndrome who are obese and those who are not. Patients and Methods: A cross-sectional study included 90 participants, ages 20–45, whose samples were collected from Al-Yarmouk-Hospital/Al-Karkh/Baghdad, from April–July/2024. Classified into three groups: group1 was obese metabolic syndrome patients (N=30), group 2 was metabolic syndrome patients without obesity (N=30), and group 3 was control (N=30). Anthropometrics and parameters were assessed for all study groups. Fasting blood glucose levels and lipid profiles were determined using an enzymatic process with spectrophotometric methods, while insulin, apelin, and Elabela were evaluated by enzyme-linked immunosorbent assay. Results: The result shows a significant difference in Body Mass Index, Waist to Hip Ratio, Lipid profile, FBS, apelin, insulin, and HOMA-IR, while there was no significant difference between the study groups in Elabela levels. In addition, there is a positive correlation between apelin and BMI, FBS, and insulin. apelin levels have a higher diagnostic value for obesity than metabolic syndrome, respectively. Conclusion: This study suggests that apelin and Elabela are powerful modulators of the metabolism of adipose cell and highlights the crucial role of apelin in MetS in both non-obese and obese MetS, as well as in clinical and biochemical markers associated with obesity. Keywords: Apelin, APJ, Elabela, Metabolic Syndrome, Obesity. http://djm.uodiyala.edu.iq/index.php/djm/article/view/1187ApelinAPJElabelaMetabolic SyndromeObesity |
| spellingShingle | Layla Imad Ali Shaimaa Imad Ali Fayhaa M. Khaleel Wasan Saher Hassan Kawther Adeeb Hussein Great Iruoghene Edo Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity Diyala Journal of Medicine Apelin APJ Elabela Metabolic Syndrome Obesity |
| title | Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity |
| title_full | Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity |
| title_fullStr | Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity |
| title_full_unstemmed | Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity |
| title_short | Evaluation of Apelin, Elabela, and Certain Biomarkers in Patients with Metabolic Disease Associated with Obesity |
| title_sort | evaluation of apelin elabela and certain biomarkers in patients with metabolic disease associated with obesity |
| topic | Apelin APJ Elabela Metabolic Syndrome Obesity |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/1187 |
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