Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study
Abstract Background Report the incidence of contralateral nodal failure rates in well-lateralized oropharyngeal carcinoma treated with upfront surgery and unilateral neck management. Methods Lateralized oropharyngeal carcinomas treated with upfront surgery using transoral robotic surgery (TORS) and...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-12-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-021-00551-9 |
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| author | Axel Sahovaler John J. W. Lee Wei Xu Susie Su Ali Hosni Andrew Bayley David P. Goldstein John R. de Almeida |
| author_facet | Axel Sahovaler John J. W. Lee Wei Xu Susie Su Ali Hosni Andrew Bayley David P. Goldstein John R. de Almeida |
| author_sort | Axel Sahovaler |
| collection | DOAJ |
| description | Abstract Background Report the incidence of contralateral nodal failure rates in well-lateralized oropharyngeal carcinoma treated with upfront surgery and unilateral neck management. Methods Lateralized oropharyngeal carcinomas treated with upfront surgery using transoral robotic surgery (TORS) and unilateral neck management (unilateral neck dissection ± unilateral radiation treatment) were identified. Primary endpoint was contralateral regional control (CRC). Secondary endpoints were local control (LC), and overall survival (OS). Results Thirty-two patients were included. Pathologic T categories included 66% pT1, 31% pT2 and 3% pT3. Nodal diseases comprised 41% N0 and 47% N1 (AJCC 8th). Twenty-three (72%) patients had HPV related tumors. 3-years CRC, LC and OS were 100%, 96% (89–100) and 96% (CI 89–100). One patient developed a second primary with contralateral nodal disease. Only one patient died from another primary cancer. Conclusion In selected patients with lateralized oropharyngeal cancer, treatment with TORS and ipsilateral management of the neck may be oncologically safe without significant risk of contralateral failure. Level of evidence: Level 2. Graphical abstract |
| format | Article |
| id | doaj-art-c91498bb15a04539a7379186be448b46 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-c91498bb15a04539a7379186be448b462025-02-03T10:54:13ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162021-12-015011810.1186/s40463-021-00551-9Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective studyAxel Sahovaler0John J. W. Lee1Wei Xu2Susie Su3Ali Hosni4Andrew Bayley5David P. Goldstein6John R. de Almeida7Department of Otolaryngology Head and Neck Surgery, University of TorontoDepartment of Otolaryngology Head and Neck Surgery, University of TorontoDepartment of Biostatistics, University of TorontoDepartment of Biostatistics, University of TorontoDepartment of Radiation Oncology, University of TorontoDepartment of Radiation Oncology, University of TorontoDepartment of Otolaryngology Head and Neck Surgery, University of TorontoDepartment of Otolaryngology Head and Neck Surgery, University of TorontoAbstract Background Report the incidence of contralateral nodal failure rates in well-lateralized oropharyngeal carcinoma treated with upfront surgery and unilateral neck management. Methods Lateralized oropharyngeal carcinomas treated with upfront surgery using transoral robotic surgery (TORS) and unilateral neck management (unilateral neck dissection ± unilateral radiation treatment) were identified. Primary endpoint was contralateral regional control (CRC). Secondary endpoints were local control (LC), and overall survival (OS). Results Thirty-two patients were included. Pathologic T categories included 66% pT1, 31% pT2 and 3% pT3. Nodal diseases comprised 41% N0 and 47% N1 (AJCC 8th). Twenty-three (72%) patients had HPV related tumors. 3-years CRC, LC and OS were 100%, 96% (89–100) and 96% (CI 89–100). One patient developed a second primary with contralateral nodal disease. Only one patient died from another primary cancer. Conclusion In selected patients with lateralized oropharyngeal cancer, treatment with TORS and ipsilateral management of the neck may be oncologically safe without significant risk of contralateral failure. Level of evidence: Level 2. Graphical abstracthttps://doi.org/10.1186/s40463-021-00551-9TORSContralateral nodal failureOropharyngeal cancer |
| spellingShingle | Axel Sahovaler John J. W. Lee Wei Xu Susie Su Ali Hosni Andrew Bayley David P. Goldstein John R. de Almeida Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study Journal of Otolaryngology - Head and Neck Surgery TORS Contralateral nodal failure Oropharyngeal cancer |
| title | Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study |
| title_full | Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study |
| title_fullStr | Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study |
| title_full_unstemmed | Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study |
| title_short | Contralateral nodal failures in oropharyngeal cancers after TORS and unilateral neck management: a retrospective study |
| title_sort | contralateral nodal failures in oropharyngeal cancers after tors and unilateral neck management a retrospective study |
| topic | TORS Contralateral nodal failure Oropharyngeal cancer |
| url | https://doi.org/10.1186/s40463-021-00551-9 |
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