Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies
Background: Ischemic stroke (IS) remains a significant global health burden, necessitating the development of novel therapeutic strategies. This study aims to systematically evaluate the therapeutic effects of mesenchymal stem cell-derived exosomes (MSC-Exos) on IS outcomes in rodent models. Methods...
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000310 |
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| author | Xiaoming Zhang Yibing Guo Kun Fang Xiangqian Huang Duo Lan Mengqi Wang Lina Jia Xunming Ji Ran Meng Da Zhou |
| author_facet | Xiaoming Zhang Yibing Guo Kun Fang Xiangqian Huang Duo Lan Mengqi Wang Lina Jia Xunming Ji Ran Meng Da Zhou |
| author_sort | Xiaoming Zhang |
| collection | DOAJ |
| description | Background: Ischemic stroke (IS) remains a significant global health burden, necessitating the development of novel therapeutic strategies. This study aims to systematically evaluate the therapeutic effects of mesenchymal stem cell-derived exosomes (MSC-Exos) on IS outcomes in rodent models. Methods: A comprehensive literature search was conducted across multiple databases to identify studies investigating the effects of MSC-Exos on rodent models of IS. Following rigorous inclusion and exclusion criteria, 73 high-quality studies were selected for meta-analysis. Primary outcomes included reductions in infarct volume/ratio and improvements in functional recovery scores. Data extraction and analysis were performed using RevMan 5.3 software. Results: Pooled data indicated that MSC-Exos administration significantly reduced infarct size and improved functional recovery scores in rodent models of IS. Treatment within 24 hours and beyond 24 hours of stroke induction both demonstrated substantial reductions in infarct volume/ratio compared to controls. Furthermore, MSC-Exos-treated groups exhibited marked improvements in functional recovery, as assessed by various neurobehavioral tests. The meta-analysis showed no significant publication bias, and heterogeneity levels were acceptable. Conclusions: MSC-Exos reveal significant therapeutic potential for IS, with evidence supporting their efficacy in reducing infarct size and enhancing functional recovery in preclinical rodent models. These findings pave the way for further research and potential clinical translation. |
| format | Article |
| id | doaj-art-c914288ca25348c1addeeaa4bd06039e |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-c914288ca25348c1addeeaa4bd06039e2025-02-07T04:46:46ZengElsevierBrain Research Bulletin1873-27472025-02-01221111219Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studiesXiaoming Zhang0Yibing Guo1Kun Fang2Xiangqian Huang3Duo Lan4Mengqi Wang5Lina Jia6Xunming Ji7Ran Meng8Da Zhou9Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaCapital Medical University, Beijing 100069, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Correspondence to: Xuanwu Hospital, Capital Medical University, Beijing 100053, China.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Correspondence to: Xuanwu Hospital, Capital Medical University, Beijing 100053, China.Background: Ischemic stroke (IS) remains a significant global health burden, necessitating the development of novel therapeutic strategies. This study aims to systematically evaluate the therapeutic effects of mesenchymal stem cell-derived exosomes (MSC-Exos) on IS outcomes in rodent models. Methods: A comprehensive literature search was conducted across multiple databases to identify studies investigating the effects of MSC-Exos on rodent models of IS. Following rigorous inclusion and exclusion criteria, 73 high-quality studies were selected for meta-analysis. Primary outcomes included reductions in infarct volume/ratio and improvements in functional recovery scores. Data extraction and analysis were performed using RevMan 5.3 software. Results: Pooled data indicated that MSC-Exos administration significantly reduced infarct size and improved functional recovery scores in rodent models of IS. Treatment within 24 hours and beyond 24 hours of stroke induction both demonstrated substantial reductions in infarct volume/ratio compared to controls. Furthermore, MSC-Exos-treated groups exhibited marked improvements in functional recovery, as assessed by various neurobehavioral tests. The meta-analysis showed no significant publication bias, and heterogeneity levels were acceptable. Conclusions: MSC-Exos reveal significant therapeutic potential for IS, with evidence supporting their efficacy in reducing infarct size and enhancing functional recovery in preclinical rodent models. These findings pave the way for further research and potential clinical translation.http://www.sciencedirect.com/science/article/pii/S0361923025000310Mesenchymal stem cellsExtracellular vesiclesIschemic strokeRodent modelsMeta-analysis |
| spellingShingle | Xiaoming Zhang Yibing Guo Kun Fang Xiangqian Huang Duo Lan Mengqi Wang Lina Jia Xunming Ji Ran Meng Da Zhou Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies Brain Research Bulletin Mesenchymal stem cells Extracellular vesicles Ischemic stroke Rodent models Meta-analysis |
| title | Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies |
| title_full | Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies |
| title_fullStr | Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies |
| title_full_unstemmed | Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies |
| title_short | Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies |
| title_sort | therapeutic potential of mesenchymal stem cell derived extracellular vesicles in ischemic stroke a meta analysis of preclinical studies |
| topic | Mesenchymal stem cells Extracellular vesicles Ischemic stroke Rodent models Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000310 |
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