Backsplicing of the HIV-1 transcript generates multiple circRNAs to promote viral replication

Abstract Circular RNAs (circRNAs) are a family of non-coding RNAs that originate from a non-canonical splicing event (backsplicing) that forms covalently closed continuous loops. An analysis of the human immunodeficiency type 1 virus (HIV-1) complex splicing pattern indicated that the virus had the...

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Bibliographic Details
Main Authors: Christopher Mauer, Sean Paz, Massimo Caputi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00105-0
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