Identification of lactylation-related biomarkers in osteoporosis from transcriptome and single-cell data

Identification of lactylation-related biomarkers in osteoporosis from transcriptome and single-cell data

BackgroundEmerging evidence indicates that lactase-mediated histone lactylation can activate osteogenic gene expression and promote bone formation. However, the role of lactylation-related genes (LRGs) in osteoporosis (OP) remains unclear. This study aims to clarify the key roles of LRGs and the mol...

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Bibliographic Details
Main Authors: Jiafeng Peng, Hongxing Zhang, Huaize Wang, Ting Jiang, Minglei Gao, Xingfu Ma, Yingzong Xiong, Yingchun Li, Ran Xu, Junchen Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
osteoporosis
lactylation
biomarkers
nomogram
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1621878/full
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