Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma
Objective To explore the changes in trace elements and amino acid profiles in serum of patients with hepatocellular carcinoma(HCC) providing a reference for clinical diagnosis and treatment.Methods A total of 104 patients with HCC who underwent surgical treatment in the Department of Hepatobiliary...
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Editorial Office of Journal of Surgery Concepts & Practice
2025-03-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751876784856-2046827133.pdf |
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| author | LUO Xi, JIANG Yongmei, MA Di, LU Qiuya, GU Xiaohan |
| author_facet | LUO Xi, JIANG Yongmei, MA Di, LU Qiuya, GU Xiaohan |
| author_sort | LUO Xi, JIANG Yongmei, MA Di, LU Qiuya, GU Xiaohan |
| collection | DOAJ |
| description | Objective To explore the changes in trace elements and amino acid profiles in serum of patients with hepatocellular carcinoma(HCC) providing a reference for clinical diagnosis and treatment.Methods A total of 104 patients with HCC who underwent surgical treatment in the Department of Hepatobiliary Surgery of our hospital from January 2024 to April 2024 were selected as the study group, and 139 patients with benign biliary diseases during the same period were selected as the control group. Atomic absorption spectrometry was used to detect the levels of six trace elements (copper, zinc, calcium, magnesium, iron, and lead) in the serum of both groups, and liquid chromatography-tandem mass spectrometry was used to measure the concentrations of 21 amino acids.Results Compared with the control group, the serum copper level in the HCC group was significantly increased (P<0.05), while the levels of zinc and iron were significantly decreased (P<0.05). Amino acid profile analysis revealed that, compared with the control group, the concentrations of tyrosine, methionine, and phenylalanine in the HCC group were increased (P<0.05), while the concentrations of valine, leucine, isoleucine, glutamine, and arginine were decreased (P<0.05). Further analysis of the correlation between trace elements and amino acids with statistical differences between the groups showed that copper was negatively correlated with valine and leucine (P<0.05), while zinc and iron were positively correlated with valine, leucine, and isoleucine (P<0.01).Conclusions Imbalances in trace elements and amino acid metabolism changes are common in patients with HCC, and there may be an intrinsic connection between the two. |
| format | Article |
| id | doaj-art-c907b9c4e7de4919820a7f778b0c062d |
| institution | DOAJ |
| issn | 1007-9610 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj-art-c907b9c4e7de4919820a7f778b0c062d2025-08-20T02:43:47ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102025-03-0130214615010.16139/j.1007-9610.2025.02.09Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinomaLUO Xi, JIANG Yongmei, MA Di, LU Qiuya, GU Xiaohan0a. Department of Clinical Nutrition, b. Department of General Surgery, Hepatobiliary Surgery, c. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaObjective To explore the changes in trace elements and amino acid profiles in serum of patients with hepatocellular carcinoma(HCC) providing a reference for clinical diagnosis and treatment.Methods A total of 104 patients with HCC who underwent surgical treatment in the Department of Hepatobiliary Surgery of our hospital from January 2024 to April 2024 were selected as the study group, and 139 patients with benign biliary diseases during the same period were selected as the control group. Atomic absorption spectrometry was used to detect the levels of six trace elements (copper, zinc, calcium, magnesium, iron, and lead) in the serum of both groups, and liquid chromatography-tandem mass spectrometry was used to measure the concentrations of 21 amino acids.Results Compared with the control group, the serum copper level in the HCC group was significantly increased (P<0.05), while the levels of zinc and iron were significantly decreased (P<0.05). Amino acid profile analysis revealed that, compared with the control group, the concentrations of tyrosine, methionine, and phenylalanine in the HCC group were increased (P<0.05), while the concentrations of valine, leucine, isoleucine, glutamine, and arginine were decreased (P<0.05). Further analysis of the correlation between trace elements and amino acids with statistical differences between the groups showed that copper was negatively correlated with valine and leucine (P<0.05), while zinc and iron were positively correlated with valine, leucine, and isoleucine (P<0.01).Conclusions Imbalances in trace elements and amino acid metabolism changes are common in patients with HCC, and there may be an intrinsic connection between the two.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751876784856-2046827133.pdf|hepatocellular carcinoma(hcc)|trace element|amino acid |
| spellingShingle | LUO Xi, JIANG Yongmei, MA Di, LU Qiuya, GU Xiaohan Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma Waike lilun yu shijian |hepatocellular carcinoma(hcc)|trace element|amino acid |
| title | Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma |
| title_full | Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma |
| title_fullStr | Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma |
| title_full_unstemmed | Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma |
| title_short | Observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma |
| title_sort | observation on changes of trace elements and amino acids in serum of patients with hepatocellular carcinoma |
| topic | |hepatocellular carcinoma(hcc)|trace element|amino acid |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751876784856-2046827133.pdf |
| work_keys_str_mv | AT luoxijiangyongmeimadiluqiuyaguxiaohan observationonchangesoftraceelementsandaminoacidsinserumofpatientswithhepatocellularcarcinoma |