Targeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primates
Abstract Background The retinoic acid receptor alpha (Rarα) has been validated as a male contraceptive target by genetic knockouts resulting in male sterility. The effects on spermatogenesis in the absence of RARα resemble the loss of RAR signaling in vitamin A deficiency, and the mice are otherwise...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-025-00752-7 |
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