Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model
Background: Bone loss is a well-documented phenomenon occurring in humans both in short- and long-term spaceflights. Revealing data on the role of erythropoietin (EPO) in bone formation has led some to suggest that EPO treatment could also play a role in protecting bone against microgravity-induced...
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Iran Air Force Health Administration
2015-04-01
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| Series: | فصلنامه ابن سینا |
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| Online Access: | http://ebnesina.ajaums.ac.ir/article-1-279-en.pdf |
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| author | A Khoshvaghti A NurMohammadi Shahin Jahani Maleki |
| author_facet | A Khoshvaghti A NurMohammadi Shahin Jahani Maleki |
| author_sort | A Khoshvaghti |
| collection | DOAJ |
| description | Background: Bone loss is a well-documented phenomenon occurring in humans both in short- and long-term spaceflights. Revealing data on the role of erythropoietin (EPO) in bone formation has led some to suggest that EPO treatment could also play a role in protecting bone against microgravity-induced bone loss. The aim of the present study was to investigate the effects of EPO administration on densitometric changes of femur of rat in a Microgravity Simulation Model (MSM). Materials and methods: Twelve rats were divided into two groups: the tail-suspended control (TSC), and the tail-suspended group treated with rhEpo (TSE) (300 U/kg every 48 hours). The experiment lasted for 3 weeks. The animals were sacrificed, the right femur of each rat was removed, and bone mineral density was measured for each animal. Results: Bone mineral density of whole femur in TSE group was significantly higher than TSC group (0.160±0.003 vs. 0.144±0.006, p=0.002). Conclusion: According to the results of this study, Erythropoietin administration might have protective effects against microgravity-induced mineral loss in a rat MSM. |
| format | Article |
| id | doaj-art-c906fffb727f46a4bd61d4f25ffe2dab |
| institution | DOAJ |
| issn | 1735-9503 2645-4653 |
| language | fas |
| publishDate | 2015-04-01 |
| publisher | Iran Air Force Health Administration |
| record_format | Article |
| series | فصلنامه ابن سینا |
| spelling | doaj-art-c906fffb727f46a4bd61d4f25ffe2dab2025-08-20T02:46:52ZfasIran Air Force Health Administrationفصلنامه ابن سینا1735-95032645-46532015-04-0117149Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation modelA Khoshvaghti0A NurMohammadi1Shahin Jahani Maleki2 Aerospace and Subaquatic Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran Aerospace and Subaquatic Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran Aerospace and Subaquatic Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran Background: Bone loss is a well-documented phenomenon occurring in humans both in short- and long-term spaceflights. Revealing data on the role of erythropoietin (EPO) in bone formation has led some to suggest that EPO treatment could also play a role in protecting bone against microgravity-induced bone loss. The aim of the present study was to investigate the effects of EPO administration on densitometric changes of femur of rat in a Microgravity Simulation Model (MSM). Materials and methods: Twelve rats were divided into two groups: the tail-suspended control (TSC), and the tail-suspended group treated with rhEpo (TSE) (300 U/kg every 48 hours). The experiment lasted for 3 weeks. The animals were sacrificed, the right femur of each rat was removed, and bone mineral density was measured for each animal. Results: Bone mineral density of whole femur in TSE group was significantly higher than TSC group (0.160±0.003 vs. 0.144±0.006, p=0.002). Conclusion: According to the results of this study, Erythropoietin administration might have protective effects against microgravity-induced mineral loss in a rat MSM.http://ebnesina.ajaums.ac.ir/article-1-279-en.pdfosteoporosisweightlessnessbone mineral densityerythropoietin |
| spellingShingle | A Khoshvaghti A NurMohammadi Shahin Jahani Maleki Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model فصلنامه ابن سینا osteoporosis weightlessness bone mineral density erythropoietin |
| title | Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model |
| title_full | Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model |
| title_fullStr | Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model |
| title_full_unstemmed | Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model |
| title_short | Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model |
| title_sort | evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model |
| topic | osteoporosis weightlessness bone mineral density erythropoietin |
| url | http://ebnesina.ajaums.ac.ir/article-1-279-en.pdf |
| work_keys_str_mv | AT akhoshvaghti evaluationtheeffectoferythropoietinonosteoporosisinamicrogravitysimulationmodel AT anurmohammadi evaluationtheeffectoferythropoietinonosteoporosisinamicrogravitysimulationmodel AT shahinjahanimaleki evaluationtheeffectoferythropoietinonosteoporosisinamicrogravitysimulationmodel |