Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review
Natural byproducts have garnered significant attention for their potential antitumorigenic properties. The current scenario sketched by the goals of circular economy approaches the research towards the utilization of agro-waste biomasses as valuable source of biological active metabolites. This comp...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001653 |
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| author | M. Verrillo V.D. Pantina V. Venezia C. Modica M. Lo Iacono P. Bianca G. Bozzari F. Angeloro V. Cozzolino G. Stassi R. Spaccini |
| author_facet | M. Verrillo V.D. Pantina V. Venezia C. Modica M. Lo Iacono P. Bianca G. Bozzari F. Angeloro V. Cozzolino G. Stassi R. Spaccini |
| author_sort | M. Verrillo |
| collection | DOAJ |
| description | Natural byproducts have garnered significant attention for their potential antitumorigenic properties. The current scenario sketched by the goals of circular economy approaches the research towards the utilization of agro-waste biomasses as valuable source of biological active metabolites. This comprehensive scientific review explores the various mechanisms through which these natural compounds exert anticancer effects, including apoptosis induction, cell cycle arrest, inhibition of angiogenesis, and suppression of metastasis. The review highlights key bioactive molecules such as polyphenols, flavonoids, alkaloids, and terpenoids, examining their molecular interactions with cancer cells. Furthermore, the potential of these natural byproducts as adjuvant therapies in combination with conventional treatments is discussed. By summarizing recent advancements and identifying future research directions, this review underscores the promise of natural byproducts from as a source of novel anticancer agents. A specific section is dedicated to outline the role of innovative materials, such as nanoparticles, hydrogels, and biopolymers, that are being developed to enhance the delivery and efficacy of active components. These carriers offer improved stability, targeted delivery, and controlled release of natural compounds, maximizing their therapeutic potential while minimizing side effects. |
| format | Article |
| id | doaj-art-c904ccb606244e068e6cb74f77cf89cf |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-c904ccb606244e068e6cb74f77cf89cf2025-08-20T02:32:19ZengElsevierPharmacological Research1096-11862025-06-0121610774010.1016/j.phrs.2025.107740Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific reviewM. Verrillo0V.D. Pantina1V. Venezia2C. Modica3M. Lo Iacono4P. Bianca5G. Bozzari6F. Angeloro7V. Cozzolino8G. Stassi9R. Spaccini10Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy; Corresponding authors.Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo 90100, ItalyDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, Naples, ItalyDepartment of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo 90100, Italy; Corresponding authors.Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo 90100, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo 90100, ItalyDepartment of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo 90100, ItalyDepartment of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo 90100, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Naples, ItalyDepartment of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo 90100, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Naples, ItalyNatural byproducts have garnered significant attention for their potential antitumorigenic properties. The current scenario sketched by the goals of circular economy approaches the research towards the utilization of agro-waste biomasses as valuable source of biological active metabolites. This comprehensive scientific review explores the various mechanisms through which these natural compounds exert anticancer effects, including apoptosis induction, cell cycle arrest, inhibition of angiogenesis, and suppression of metastasis. The review highlights key bioactive molecules such as polyphenols, flavonoids, alkaloids, and terpenoids, examining their molecular interactions with cancer cells. Furthermore, the potential of these natural byproducts as adjuvant therapies in combination with conventional treatments is discussed. By summarizing recent advancements and identifying future research directions, this review underscores the promise of natural byproducts from as a source of novel anticancer agents. A specific section is dedicated to outline the role of innovative materials, such as nanoparticles, hydrogels, and biopolymers, that are being developed to enhance the delivery and efficacy of active components. These carriers offer improved stability, targeted delivery, and controlled release of natural compounds, maximizing their therapeutic potential while minimizing side effects.http://www.sciencedirect.com/science/article/pii/S1043661825001653Natural productAgro-foodAnti-tumorMultifunctional materialsBiowaste valorization |
| spellingShingle | M. Verrillo V.D. Pantina V. Venezia C. Modica M. Lo Iacono P. Bianca G. Bozzari F. Angeloro V. Cozzolino G. Stassi R. Spaccini Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review Pharmacological Research Natural product Agro-food Anti-tumor Multifunctional materials Biowaste valorization |
| title | Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review |
| title_full | Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review |
| title_fullStr | Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review |
| title_full_unstemmed | Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review |
| title_short | Exploring the antitumorigenic properties of agro-food byproducts: A comprehensive scientific review |
| title_sort | exploring the antitumorigenic properties of agro food byproducts a comprehensive scientific review |
| topic | Natural product Agro-food Anti-tumor Multifunctional materials Biowaste valorization |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001653 |
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