Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved]
Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous research suggests that people with bipolar disorder...
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| Language: | English |
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Wellcome
2024-10-01
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| Series: | Wellcome Open Research |
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| Online Access: | https://wellcomeopenresearch.org/articles/9-64/v2 |
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| author | Amber Roguski Iain H. Campbell Lyle Armstrong Amy Ferguson Baljean Dhillon Majlinda Lako Gerrit Hilgen Jasna Martinovic Tom MacGillivray Renata L. Riha Nicole Needham Nayantara Santhi Philipp Ritter Manuel Spitschan Malcolm von Schantz Daniel J. Smith |
| author_facet | Amber Roguski Iain H. Campbell Lyle Armstrong Amy Ferguson Baljean Dhillon Majlinda Lako Gerrit Hilgen Jasna Martinovic Tom MacGillivray Renata L. Riha Nicole Needham Nayantara Santhi Philipp Ritter Manuel Spitschan Malcolm von Schantz Daniel J. Smith |
| author_sort | Amber Roguski |
| collection | DOAJ |
| description | Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous research suggests that people with bipolar disorder might have a heightened sensitivity to light, causing more circadian rhythm disruption, increasing the potential for triggering a mood switch into mania or depression. Lithium has been in clinical use for over 70 years and is acknowledged to be the most effective long-term treatment for bipolar disorder. Lithium has many reported actions in the body but the precise mechanism of action in bipolar disorder remains an active area of research. Central to this project is recent evidence that lithium may work by stabilising circadian rhythms of mood, cognition and rest/activity. Our primary hypothesis is that people with bipolar disorder have some pathophysiological change at the level of the retina which makes them hypersensitive to the visual and non-visual effects of light, and therefore more susceptible to circadian rhythm dysfunction. We additionally hypothesise that the mood-stabilising medication lithium is effective in bipolar disorder because it reduces this hypersensitivity, making individuals less vulnerable to light-induced circadian disruption. We will recruit 180 participants into the HELIOS-BD study. Over an 18-month period, we will assess visual and non-visual responses to light, as well as retinal microstructure, in people with bipolar disorder compared to healthy controls. Further, we will assess whether individuals with bipolar disorder who are being treated with lithium have less pronounced light responses and attenuated retinal changes compared to individuals with bipolar disorder not being treated with lithium. This study represents a comprehensive investigation of visual and non-visual light responses in a large bipolar disorder population, with great translational potential for patient stratification and treatment innovation. |
| format | Article |
| id | doaj-art-c903e42ee15b4fbe8e18c6f8855e8a13 |
| institution | OA Journals |
| issn | 2398-502X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj-art-c903e42ee15b4fbe8e18c6f8855e8a132025-08-20T01:48:02ZengWellcomeWellcome Open Research2398-502X2024-10-01910.12688/wellcomeopenres.20557.225555Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved]Amber Roguski0https://orcid.org/0000-0002-5934-7311Iain H. Campbell1Lyle Armstrong2Amy Ferguson3Baljean Dhillon4Majlinda Lako5Gerrit Hilgen6Jasna Martinovic7Tom MacGillivray8https://orcid.org/0000-0001-5120-0086Renata L. Riha9Nicole Needham10https://orcid.org/0000-0002-3610-1669Nayantara Santhi11Philipp Ritter12https://orcid.org/0000-0003-4286-5830Manuel Spitschan13Malcolm von Schantz14Daniel J. Smith15https://orcid.org/0000-0002-2267-1951Division of Psychiatry, The University of Edinburgh, Edinburgh, Scotland, UKDivision of Psychiatry, The University of Edinburgh, Edinburgh, Scotland, UKFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, UKDivision of Psychiatry, The University of Edinburgh, Edinburgh, Scotland, UKCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UKFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, UKFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UKDepartment of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, Scotland, UKCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UKCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UKDivision of Psychiatry, The University of Edinburgh, Edinburgh, Scotland, UKFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UKClinic for Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universitat Dresden, Dresden, Saxony, GermanyTUM School of Medicine & Health, Department of Health and Sport Sciences, Technical University of Munich, Munich, Bavaria, GermanyFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UKDivision of Psychiatry, The University of Edinburgh, Edinburgh, Scotland, UKMany people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous research suggests that people with bipolar disorder might have a heightened sensitivity to light, causing more circadian rhythm disruption, increasing the potential for triggering a mood switch into mania or depression. Lithium has been in clinical use for over 70 years and is acknowledged to be the most effective long-term treatment for bipolar disorder. Lithium has many reported actions in the body but the precise mechanism of action in bipolar disorder remains an active area of research. Central to this project is recent evidence that lithium may work by stabilising circadian rhythms of mood, cognition and rest/activity. Our primary hypothesis is that people with bipolar disorder have some pathophysiological change at the level of the retina which makes them hypersensitive to the visual and non-visual effects of light, and therefore more susceptible to circadian rhythm dysfunction. We additionally hypothesise that the mood-stabilising medication lithium is effective in bipolar disorder because it reduces this hypersensitivity, making individuals less vulnerable to light-induced circadian disruption. We will recruit 180 participants into the HELIOS-BD study. Over an 18-month period, we will assess visual and non-visual responses to light, as well as retinal microstructure, in people with bipolar disorder compared to healthy controls. Further, we will assess whether individuals with bipolar disorder who are being treated with lithium have less pronounced light responses and attenuated retinal changes compared to individuals with bipolar disorder not being treated with lithium. This study represents a comprehensive investigation of visual and non-visual light responses in a large bipolar disorder population, with great translational potential for patient stratification and treatment innovation.https://wellcomeopenresearch.org/articles/9-64/v2Bipolar disorder lithium melatonin light sensitivity circadian rhythm visioneng |
| spellingShingle | Amber Roguski Iain H. Campbell Lyle Armstrong Amy Ferguson Baljean Dhillon Majlinda Lako Gerrit Hilgen Jasna Martinovic Tom MacGillivray Renata L. Riha Nicole Needham Nayantara Santhi Philipp Ritter Manuel Spitschan Malcolm von Schantz Daniel J. Smith Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] Wellcome Open Research Bipolar disorder lithium melatonin light sensitivity circadian rhythm vision eng |
| title | Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] |
| title_full | Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] |
| title_fullStr | Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] |
| title_full_unstemmed | Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] |
| title_short | Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] |
| title_sort | investigating light sensitivity in bipolar disorder helios bd version 2 peer review 2 approved |
| topic | Bipolar disorder lithium melatonin light sensitivity circadian rhythm vision eng |
| url | https://wellcomeopenresearch.org/articles/9-64/v2 |
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