Deletion of gE in Herpes Simplex Virus 1 Leads to Increased Extracellular Virus Production and Augmented Interferon Alpha Production by Peripheral Blood Mononuclear Cells

Deletion of gE in Herpes Simplex Virus 1 Leads to Increased Extracellular Virus Production and Augmented Interferon Alpha Production by Peripheral Blood Mononuclear Cells

Herpes simplex virus (HSV) in humans and pseudorabies virus (PRV) in pigs are both alphaherpesviruses. Plasmacytoid dendritic cells (pDCs) make part of the peripheral blood mononuclear cells (PBMCs) and are specialized in producing large amounts of antiviral type I interferon (IFN-I). IFN-I producti...

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Bibliographic Details
Main Authors: Manon Claeys, Jonas Delva, Cedric Jacqmotte, Cliff Van Waesberghe, Herman W. Favoreel
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pathogens
Subjects:
HSV-1
glycoprotein E
type I interferon
peripheral blood mononuclear cells
plasmacytoid dendritic cell
Online Access:https://www.mdpi.com/2076-0817/13/12/1138
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