Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation

Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation

Abstract Multiple lines of evidence indicate that immune signaling can impact the pathological progression in Alzheimer’s disease (AD), including amyloid deposition, tau aggregation, synaptic pathology and neurodegenerative trajectory. In earlier studies, we reported that intracerebral expression of...

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Main Authors: Emily J. Koller, Karen N. McFarland, Conner Angelle, John Howard, Danny Ryu, Kristy D. Dillon, Aya Erquizi, Mihir Beheray, Elsa Gonzalez De La Cruz, Pedro E. Cruz, Jada Lewis, Todd E. Golde, Yona Levites, Paramita Chakrabarty
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Acta Neuropathologica Communications
Subjects:
Soluble receptor
Il10
Il4
Amyloid
Tau
Therapy
Online Access:https://doi.org/10.1186/s40478-025-01968-3
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https://doi.org/10.1186/s40478-025-01968-3

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