Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy
33 patients with active, moderate-severe Graves’ ophthalmopathy (GO) received 4.5 g methylprednisolone for 12 weeks and were divided by efficacy into two groups (responsive and unresponsive). All patients and 10 controls underwent orbital MRI examination at baseline. No significant difference was se...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/3196059 |
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| author | Lingling Xu Linna Li Cuihua Xie Meiping Guan Yaoming Xue |
| author_facet | Lingling Xu Linna Li Cuihua Xie Meiping Guan Yaoming Xue |
| author_sort | Lingling Xu |
| collection | DOAJ |
| description | 33 patients with active, moderate-severe Graves’ ophthalmopathy (GO) received 4.5 g methylprednisolone for 12 weeks and were divided by efficacy into two groups (responsive and unresponsive). All patients and 10 controls underwent orbital MRI examination at baseline. No significant difference was seen in baseline clinical characteristics between the two GO groups. The values of exophthalmos were higher in both GO groups than in the control and were higher in the responsive group versus the unresponsive group. Compared to the unresponsive group, the responsive group had a thicker inferior rectus as well as thinner orbital fat. The inferior rectus/fat ratio was significantly higher in the responsive group versus the unresponsive group. Multivariate logistic regression analysis showed that the exophthalmos value and inferior rectus/fat ratio were significantly associated with the response to glucocorticoid (GC). ROC analysis revealed that the cut-off points of the inferior rectus/fat ratio combined with the exophthalmos value to indicate efficacy were 1.42 and 20.78. For moderate-severe GO patients with CAS > 3, the combined inferior rectus/fat ratio and exophthalmos value in MRI may be a valuable indicator to predict the response to GC therapy. |
| format | Article |
| id | doaj-art-c8f9f4c9740f4be68623ba40478530d4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-c8f9f4c9740f4be68623ba40478530d42025-08-20T03:24:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/31960593196059Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ OphthalmopathyLingling Xu0Linna Li1Cuihua Xie2Meiping Guan3Yaoming Xue4Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaDepartment of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaDepartment of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaDepartment of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, ChinaDepartment of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China33 patients with active, moderate-severe Graves’ ophthalmopathy (GO) received 4.5 g methylprednisolone for 12 weeks and were divided by efficacy into two groups (responsive and unresponsive). All patients and 10 controls underwent orbital MRI examination at baseline. No significant difference was seen in baseline clinical characteristics between the two GO groups. The values of exophthalmos were higher in both GO groups than in the control and were higher in the responsive group versus the unresponsive group. Compared to the unresponsive group, the responsive group had a thicker inferior rectus as well as thinner orbital fat. The inferior rectus/fat ratio was significantly higher in the responsive group versus the unresponsive group. Multivariate logistic regression analysis showed that the exophthalmos value and inferior rectus/fat ratio were significantly associated with the response to glucocorticoid (GC). ROC analysis revealed that the cut-off points of the inferior rectus/fat ratio combined with the exophthalmos value to indicate efficacy were 1.42 and 20.78. For moderate-severe GO patients with CAS > 3, the combined inferior rectus/fat ratio and exophthalmos value in MRI may be a valuable indicator to predict the response to GC therapy.http://dx.doi.org/10.1155/2017/3196059 |
| spellingShingle | Lingling Xu Linna Li Cuihua Xie Meiping Guan Yaoming Xue Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy International Journal of Endocrinology |
| title | Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy |
| title_full | Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy |
| title_fullStr | Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy |
| title_full_unstemmed | Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy |
| title_short | Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy |
| title_sort | thickness of extraocular muscle and orbital fat in mri predicts response to glucocorticoid therapy in graves ophthalmopathy |
| url | http://dx.doi.org/10.1155/2017/3196059 |
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