An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers.
Neuroblastoma is the commonest extra cranial solid cancer of childhood. Despite escalation of treatment regimens, a significant minority of patients die of their disease. Disialoganglioside (GD2) is consistently expressed at high-levels in neuroblastoma tumors, which have been targeted with some suc...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152196&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850133460227719168 |
|---|---|
| author | Simon Thomas Karin Straathof Nourredine Himoudi John Anderson Martin Pule |
| author_facet | Simon Thomas Karin Straathof Nourredine Himoudi John Anderson Martin Pule |
| author_sort | Simon Thomas |
| collection | DOAJ |
| description | Neuroblastoma is the commonest extra cranial solid cancer of childhood. Despite escalation of treatment regimens, a significant minority of patients die of their disease. Disialoganglioside (GD2) is consistently expressed at high-levels in neuroblastoma tumors, which have been targeted with some success using therapeutic monoclonal antibodies. GD2 is also expressed in a range of other cancer but with the exception of some peripheral nerves is largely absent from non-transformed tissues. Chimeric Antigen Receptors (CARs) are artificial type I proteins which graft the specificity of a monoclonal antibody onto a T-cell. Clinical data with early CAR designs directed against GD2 have shown some promise in Neuroblastoma. Here, we describe a GD2-targeting CAR retroviral cassette, which has been optimized for CAR T-cell persistence, efficacy and safety. |
| format | Article |
| id | doaj-art-c8f866882b6a485f9cedff2ddec12d77 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c8f866882b6a485f9cedff2ddec12d772025-08-20T02:31:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015219610.1371/journal.pone.0152196An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers.Simon ThomasKarin StraathofNourredine HimoudiJohn AndersonMartin PuleNeuroblastoma is the commonest extra cranial solid cancer of childhood. Despite escalation of treatment regimens, a significant minority of patients die of their disease. Disialoganglioside (GD2) is consistently expressed at high-levels in neuroblastoma tumors, which have been targeted with some success using therapeutic monoclonal antibodies. GD2 is also expressed in a range of other cancer but with the exception of some peripheral nerves is largely absent from non-transformed tissues. Chimeric Antigen Receptors (CARs) are artificial type I proteins which graft the specificity of a monoclonal antibody onto a T-cell. Clinical data with early CAR designs directed against GD2 have shown some promise in Neuroblastoma. Here, we describe a GD2-targeting CAR retroviral cassette, which has been optimized for CAR T-cell persistence, efficacy and safety.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152196&type=printable |
| spellingShingle | Simon Thomas Karin Straathof Nourredine Himoudi John Anderson Martin Pule An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. PLoS ONE |
| title | An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. |
| title_full | An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. |
| title_fullStr | An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. |
| title_full_unstemmed | An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. |
| title_short | An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. |
| title_sort | optimized gd2 targeting retroviral cassette for more potent and safer cellular therapy of neuroblastoma and other cancers |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152196&type=printable |
| work_keys_str_mv | AT simonthomas anoptimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT karinstraathof anoptimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT nourredinehimoudi anoptimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT johnanderson anoptimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT martinpule anoptimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT simonthomas optimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT karinstraathof optimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT nourredinehimoudi optimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT johnanderson optimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers AT martinpule optimizedgd2targetingretroviralcassetteformorepotentandsafercellulartherapyofneuroblastomaandothercancers |