Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A
The in vitro and in vivo evidence compatible with a role for oxidative stress in OTA carcinogenicity has been collected and described. Several potential oxido-reduction mechanisms have been identified in the past. More recently, the possibility of a reduction of cellular antioxidant defense has been...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/645361 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473341614718976 |
|---|---|
| author | M. Marin-Kuan V. Ehrlich T. Delatour C. Cavin B. Schilter |
| author_facet | M. Marin-Kuan V. Ehrlich T. Delatour C. Cavin B. Schilter |
| author_sort | M. Marin-Kuan |
| collection | DOAJ |
| description | The in vitro and in vivo evidence compatible with a role for oxidative stress in OTA carcinogenicity has been collected and described. Several potential oxido-reduction mechanisms have been identified in the past. More recently, the possibility of a reduction of cellular antioxidant defense has been raised as an indirect source of oxidative stress. Consequences resulting from the production of oxidative stress are observed at different levels. First, OTA exposure has been associated with increased levels of oxidative DNA, lipid, and protein damage. Second, various biological processes known to be mobilized under oxidative stress were shown to be altered by OTA. These effects have been observed in both in vitro and in vivo test systems. In vivo, active doses were often within doses documented to induce renal tumors in rats. In conclusion, the evidence for the induction of an oxidative stress response resulting from OTA exposure can be considered strong. Because the contribution of the oxidative stress response in the development of cancers is well established, a role in OTA carcinogenicity is plausible. Altogether, the data reviewed above support the application of a threshold-based approach to establish safe level of dietary human exposure to OTA. |
| format | Article |
| id | doaj-art-c8f5a2e27a354a8d8a140d9dcdb3db64 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-c8f5a2e27a354a8d8a140d9dcdb3db642025-08-20T03:24:11ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/645361645361Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin AM. Marin-Kuan0V. Ehrlich1T. Delatour2C. Cavin3B. Schilter4Chemical Food Safety Group, Quality & Safety Department, Nestlé Research Center, P.O. Box 44, Vers-chez-les-Blanc, 1000 Lausanne 26, SwitzerlandChemical Food Safety Group, Quality & Safety Department, Nestlé Research Center, P.O. Box 44, Vers-chez-les-Blanc, 1000 Lausanne 26, SwitzerlandChemical Food Safety Group, Quality & Safety Department, Nestlé Research Center, P.O. Box 44, Vers-chez-les-Blanc, 1000 Lausanne 26, SwitzerlandChemical Food Safety Group, Quality & Safety Department, Nestlé Research Center, P.O. Box 44, Vers-chez-les-Blanc, 1000 Lausanne 26, SwitzerlandChemical Food Safety Group, Quality & Safety Department, Nestlé Research Center, P.O. Box 44, Vers-chez-les-Blanc, 1000 Lausanne 26, SwitzerlandThe in vitro and in vivo evidence compatible with a role for oxidative stress in OTA carcinogenicity has been collected and described. Several potential oxido-reduction mechanisms have been identified in the past. More recently, the possibility of a reduction of cellular antioxidant defense has been raised as an indirect source of oxidative stress. Consequences resulting from the production of oxidative stress are observed at different levels. First, OTA exposure has been associated with increased levels of oxidative DNA, lipid, and protein damage. Second, various biological processes known to be mobilized under oxidative stress were shown to be altered by OTA. These effects have been observed in both in vitro and in vivo test systems. In vivo, active doses were often within doses documented to induce renal tumors in rats. In conclusion, the evidence for the induction of an oxidative stress response resulting from OTA exposure can be considered strong. Because the contribution of the oxidative stress response in the development of cancers is well established, a role in OTA carcinogenicity is plausible. Altogether, the data reviewed above support the application of a threshold-based approach to establish safe level of dietary human exposure to OTA.http://dx.doi.org/10.1155/2011/645361 |
| spellingShingle | M. Marin-Kuan V. Ehrlich T. Delatour C. Cavin B. Schilter Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A Journal of Toxicology |
| title | Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A |
| title_full | Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A |
| title_fullStr | Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A |
| title_full_unstemmed | Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A |
| title_short | Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A |
| title_sort | evidence for a role of oxidative stress in the carcinogenicity of ochratoxin a |
| url | http://dx.doi.org/10.1155/2011/645361 |
| work_keys_str_mv | AT mmarinkuan evidenceforaroleofoxidativestressinthecarcinogenicityofochratoxina AT vehrlich evidenceforaroleofoxidativestressinthecarcinogenicityofochratoxina AT tdelatour evidenceforaroleofoxidativestressinthecarcinogenicityofochratoxina AT ccavin evidenceforaroleofoxidativestressinthecarcinogenicityofochratoxina AT bschilter evidenceforaroleofoxidativestressinthecarcinogenicityofochratoxina |