Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES
The association between heavy metal exposure and diabetes is controversial and vitamin E (VE) may reduce diabetes risk. We aimed to examine the associations between blood heavy metals (BHMs) and diabetes risk and VE’s role in the relationship. From the 2007–2018 NHANES, 10,721 participants aged ≥ 18...
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2024-12-01
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| author | Chenggang Yang Shimiao Dai Yutian Luo Qingqing Lv Junying Zhu Aolin Yang Zhan Shi Ziyu Han Ruirui Yu Jialei Yang Longjian Liu Ji-Chang Zhou |
| author_facet | Chenggang Yang Shimiao Dai Yutian Luo Qingqing Lv Junying Zhu Aolin Yang Zhan Shi Ziyu Han Ruirui Yu Jialei Yang Longjian Liu Ji-Chang Zhou |
| author_sort | Chenggang Yang |
| collection | DOAJ |
| description | The association between heavy metal exposure and diabetes is controversial and vitamin E (VE) may reduce diabetes risk. We aimed to examine the associations between blood heavy metals (BHMs) and diabetes risk and VE’s role in the relationship. From the 2007–2018 NHANES, 10,721 participants aged ≥ 18 were included for multiple statistical analyses, which revealed that BHMs and dietary VE intake were negatively associated with diabetes and fasting plasma glucose (FPG). The diabetes prevalence in each quartile (Q) of heavy metal exposure increased with age, but within age Q4, it generally decreased with exposure quartiles. Moreover, BHMs were positively associated with all-cause and diabetes-related mortalities with aging, which induced an age breakpoint of 65 years for age-stratified analyses on the associations between BHMs and diabetes risk. In those aged > 65, BHMs were negatively correlated with diabetes risk and its biomarkers; however, in adults aged 18–65, the correlation was positive. At higher VE intake levels, blood lead was associated with a lower diabetes risk and all three BHMs demonstrated lower FPG levels than those at lower VE intake levels. In conclusion, consuming sufficient VE and avoiding heavy metal exposure are highly recommended to reduce diabetes risk. |
| format | Article |
| id | doaj-art-c8f4b4dabaf14830b7190485642d6ddc |
| institution | Kabale University |
| issn | 2305-6304 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-c8f4b4dabaf14830b7190485642d6ddc2025-01-24T13:50:55ZengMDPI AGToxics2305-63042024-12-01131910.3390/toxics13010009Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANESChenggang Yang0Shimiao Dai1Yutian Luo2Qingqing Lv3Junying Zhu4Aolin Yang5Zhan Shi6Ziyu Han7Ruirui Yu8Jialei Yang9Longjian Liu10Ji-Chang Zhou11School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health, Columbia University, New York, NY 10025, USASchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USASchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaThe association between heavy metal exposure and diabetes is controversial and vitamin E (VE) may reduce diabetes risk. We aimed to examine the associations between blood heavy metals (BHMs) and diabetes risk and VE’s role in the relationship. From the 2007–2018 NHANES, 10,721 participants aged ≥ 18 were included for multiple statistical analyses, which revealed that BHMs and dietary VE intake were negatively associated with diabetes and fasting plasma glucose (FPG). The diabetes prevalence in each quartile (Q) of heavy metal exposure increased with age, but within age Q4, it generally decreased with exposure quartiles. Moreover, BHMs were positively associated with all-cause and diabetes-related mortalities with aging, which induced an age breakpoint of 65 years for age-stratified analyses on the associations between BHMs and diabetes risk. In those aged > 65, BHMs were negatively correlated with diabetes risk and its biomarkers; however, in adults aged 18–65, the correlation was positive. At higher VE intake levels, blood lead was associated with a lower diabetes risk and all three BHMs demonstrated lower FPG levels than those at lower VE intake levels. In conclusion, consuming sufficient VE and avoiding heavy metal exposure are highly recommended to reduce diabetes risk.https://www.mdpi.com/2305-6304/13/1/9heavy metalsdiabetesglucose metabolic biomarkersvitamin Emortalityage-stratified analysis |
| spellingShingle | Chenggang Yang Shimiao Dai Yutian Luo Qingqing Lv Junying Zhu Aolin Yang Zhan Shi Ziyu Han Ruirui Yu Jialei Yang Longjian Liu Ji-Chang Zhou Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES Toxics heavy metals diabetes glucose metabolic biomarkers vitamin E mortality age-stratified analysis |
| title | Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES |
| title_full | Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES |
| title_fullStr | Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES |
| title_full_unstemmed | Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES |
| title_short | Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18–65 Years: Findings from 2007–2018 NHANES |
| title_sort | vitamin e intake attenuated the association between elevated blood heavy metal pb cd and hg concentrations and diabetes risk in adults aged 18 65 years findings from 2007 2018 nhanes |
| topic | heavy metals diabetes glucose metabolic biomarkers vitamin E mortality age-stratified analysis |
| url | https://www.mdpi.com/2305-6304/13/1/9 |
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