Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation
Emerging insights have been approached that gut microbiota act as a critical regulator for ionizing radiation (IR)-induced damage. Herein, an available strategy has been explored to shape gut microbiota for radioprotection by loading curcumin (Cur) into ginger-derived vesicle-like nanoparticles (GDN...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2531210 |
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| author | Xinrui Zhang Qian Cui Li Yin Jin Zhu Yinghua Mao Rong Yin Hao Shao Wenjing Wang Xuewei Sun Zhuohan Zhang Chunyan Gu Mingyan Zhang Ruonan Zhang Han Lu Zhipeng Cai Hong Li Zhan Yang |
| author_facet | Xinrui Zhang Qian Cui Li Yin Jin Zhu Yinghua Mao Rong Yin Hao Shao Wenjing Wang Xuewei Sun Zhuohan Zhang Chunyan Gu Mingyan Zhang Ruonan Zhang Han Lu Zhipeng Cai Hong Li Zhan Yang |
| author_sort | Xinrui Zhang |
| collection | DOAJ |
| description | Emerging insights have been approached that gut microbiota act as a critical regulator for ionizing radiation (IR)-induced damage. Herein, an available strategy has been explored to shape gut microbiota for radioprotection by loading curcumin (Cur) into ginger-derived vesicle-like nanoparticles (GDNs). Engineered biomimetic nanovesicles (GDN-Cur) exhibited superb stability in the gastrointestinal tract, thereby significantly enhancing the oral bioavailability of Cur. Consequently, the intrinsic antioxidative, anti-inflammatory, and anti-apoptotic properties of GDNs and Cur granted this nanosystem exceptional protective effect against IR-induced injuries, especially in mitigating intestinal damage. Particularly, the dysbacteriosis triggered by IR could be counteracted through the oral administration of GDN-Cur, resulting in gut microbiota regulation-mediated syndrome mitigation. Furthermore, elevated abundances of Akkermansia muciniphila (A. muciniphila), a bacterial strain of Akkermansia taxa responsive to GDN-Cur, especially their supernatants, were associated with post-radiation protection of intestinal function. This beneficial effect was attributed to the identified radioprotective metabolites secreted by A. muciniphila, such as tanespimycin (17-AAG), which was demonstrated to deactivate AKT/NF-κB signaling pathway. These findings reveal the impact of plant products on radioprotective microbes and metabolites to target host processes and alleviate IR-induced intestinal damage, shedding light on new insights in the development of novel radioprotectants. |
| format | Article |
| id | doaj-art-c8f2c9cbeae54879b352aac7d434a96f |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-c8f2c9cbeae54879b352aac7d434a96f2025-08-20T03:12:01ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2531210Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulationXinrui Zhang0Qian Cui1Li Yin2Jin Zhu3Yinghua Mao4Rong Yin5Hao Shao6Wenjing Wang7Xuewei Sun8Zhuohan Zhang9Chunyan Gu10Mingyan Zhang11Ruonan Zhang12Han Lu13Zhipeng Cai14Hong Li15Zhan Yang16School of Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Respiratory Medicine, Air Force Hospital of Eastern Theater, Nanjing, ChinaDepartment of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Thoracic Surgery, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, ChinaTeachers College, Columbia University, New York, USADepartment of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaSchool of Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaDepartment of Microbiology, Huadong Research Institute for Medicine and Biotechniques, Nanjing, ChinaEmerging insights have been approached that gut microbiota act as a critical regulator for ionizing radiation (IR)-induced damage. Herein, an available strategy has been explored to shape gut microbiota for radioprotection by loading curcumin (Cur) into ginger-derived vesicle-like nanoparticles (GDNs). Engineered biomimetic nanovesicles (GDN-Cur) exhibited superb stability in the gastrointestinal tract, thereby significantly enhancing the oral bioavailability of Cur. Consequently, the intrinsic antioxidative, anti-inflammatory, and anti-apoptotic properties of GDNs and Cur granted this nanosystem exceptional protective effect against IR-induced injuries, especially in mitigating intestinal damage. Particularly, the dysbacteriosis triggered by IR could be counteracted through the oral administration of GDN-Cur, resulting in gut microbiota regulation-mediated syndrome mitigation. Furthermore, elevated abundances of Akkermansia muciniphila (A. muciniphila), a bacterial strain of Akkermansia taxa responsive to GDN-Cur, especially their supernatants, were associated with post-radiation protection of intestinal function. This beneficial effect was attributed to the identified radioprotective metabolites secreted by A. muciniphila, such as tanespimycin (17-AAG), which was demonstrated to deactivate AKT/NF-κB signaling pathway. These findings reveal the impact of plant products on radioprotective microbes and metabolites to target host processes and alleviate IR-induced intestinal damage, shedding light on new insights in the development of novel radioprotectants.https://www.tandfonline.com/doi/10.1080/19490976.2025.2531210Ionizing radiation-induced intestinal damageginger-derived vesicle-like nanoparticlescurcumingut microbiotametabolitesradioprotection |
| spellingShingle | Xinrui Zhang Qian Cui Li Yin Jin Zhu Yinghua Mao Rong Yin Hao Shao Wenjing Wang Xuewei Sun Zhuohan Zhang Chunyan Gu Mingyan Zhang Ruonan Zhang Han Lu Zhipeng Cai Hong Li Zhan Yang Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation Gut Microbes Ionizing radiation-induced intestinal damage ginger-derived vesicle-like nanoparticles curcumin gut microbiota metabolites radioprotection |
| title | Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation |
| title_full | Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation |
| title_fullStr | Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation |
| title_full_unstemmed | Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation |
| title_short | Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation |
| title_sort | ginger derived vesicle like nanoparticles loaded with curcumin to alleviate ionizing radiation induced intestinal damage via gut microbiota regulation |
| topic | Ionizing radiation-induced intestinal damage ginger-derived vesicle-like nanoparticles curcumin gut microbiota metabolites radioprotection |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2531210 |
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