A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant
The present study reveals in vitro antioxidant properties and the phytochemical content of a novel Rheum species (Rheum telianum), which grows in Southeastern Anatolia. To perform the analysis, dried leaves and seeds of the plants were ground and extracted with ethanol to obtain plant secondary meta...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Food Chemistry: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590157524010137 |
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| author | Ahmet Zafer Tel Kubra Aslan Mustafa Abdullah Yılmaz İlhami Gulcin |
| author_facet | Ahmet Zafer Tel Kubra Aslan Mustafa Abdullah Yılmaz İlhami Gulcin |
| author_sort | Ahmet Zafer Tel |
| collection | DOAJ |
| description | The present study reveals in vitro antioxidant properties and the phytochemical content of a novel Rheum species (Rheum telianum), which grows in Southeastern Anatolia. To perform the analysis, dried leaves and seeds of the plants were ground and extracted with ethanol to obtain plant secondary metabolites and antioxidant activity. Then, dried extracts were subjected to in vitro DPPH scavenging and Cupric reducing (CUPRAC), Fe3+, and Ferric reducing antioxidant power (FRAP). In addition to the antioxidant capacity assays, quantitative phenolic, flavonoid, and secondary metabolite were determined through spectrophotometric and LC-MS/MS chromatographic methods. IC50 values showed that both leaves and the seeds of the R. telianum have high inhibitory properties over DPPH radicals with 20.79 and 5.67 μg/mL, respectively. The samples' dominant secondary metabolites were evaluated through the LC-MS/MS analysis results. The inhibition effects of both leaves and the seeds of the R. telianum extracts on acetylcholinesterase and butyrylcholinesterase, α-glycosidase and human carbonic anhydrases II isoenzyme enzymes, which associated with some global diseases including Alzheimer's disease, type-2 diabetes mellitus and glaucoma were determined. In conclusion, the extracts' contents and functional relationship and the plants' possible usage in the food, medicine, and cosmetic industries was revealed. |
| format | Article |
| id | doaj-art-c8effc4825c945fea1cc8139989c75c4 |
| institution | Kabale University |
| issn | 2590-1575 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry: X |
| spelling | doaj-art-c8effc4825c945fea1cc8139989c75c42025-02-12T05:32:06ZengElsevierFood Chemistry: X2590-15752025-01-0125102125A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plantAhmet Zafer Tel0Kubra Aslan1Mustafa Abdullah Yılmaz2İlhami Gulcin3Department of Agricultural Biotechnology, Faculty of Agriculture, Igdir University, 76000 Igdir, Türkiye; Corresponding authors.Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, TürkiyeFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Dicle University, 21280 Diyarbakır, TürkiyeDepartment of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Türkiye; Corresponding authors.The present study reveals in vitro antioxidant properties and the phytochemical content of a novel Rheum species (Rheum telianum), which grows in Southeastern Anatolia. To perform the analysis, dried leaves and seeds of the plants were ground and extracted with ethanol to obtain plant secondary metabolites and antioxidant activity. Then, dried extracts were subjected to in vitro DPPH scavenging and Cupric reducing (CUPRAC), Fe3+, and Ferric reducing antioxidant power (FRAP). In addition to the antioxidant capacity assays, quantitative phenolic, flavonoid, and secondary metabolite were determined through spectrophotometric and LC-MS/MS chromatographic methods. IC50 values showed that both leaves and the seeds of the R. telianum have high inhibitory properties over DPPH radicals with 20.79 and 5.67 μg/mL, respectively. The samples' dominant secondary metabolites were evaluated through the LC-MS/MS analysis results. The inhibition effects of both leaves and the seeds of the R. telianum extracts on acetylcholinesterase and butyrylcholinesterase, α-glycosidase and human carbonic anhydrases II isoenzyme enzymes, which associated with some global diseases including Alzheimer's disease, type-2 diabetes mellitus and glaucoma were determined. In conclusion, the extracts' contents and functional relationship and the plants' possible usage in the food, medicine, and cosmetic industries was revealed.http://www.sciencedirect.com/science/article/pii/S2590157524010137Rheum telianumAntioxidant activityAcetylcholinesterase;α-glycosidaseRhubarbPhenolic compound |
| spellingShingle | Ahmet Zafer Tel Kubra Aslan Mustafa Abdullah Yılmaz İlhami Gulcin A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant Food Chemistry: X Rheum telianum Antioxidant activity Acetylcholinesterase;α-glycosidase Rhubarb Phenolic compound |
| title | A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant |
| title_full | A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant |
| title_fullStr | A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant |
| title_full_unstemmed | A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant |
| title_short | A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant |
| title_sort | multidimensional study for design of phytochemical profiling antioxidant potential and enzyme inhibition effects of isgin rheum telianum as an edible plant |
| topic | Rheum telianum Antioxidant activity Acetylcholinesterase;α-glycosidase Rhubarb Phenolic compound |
| url | http://www.sciencedirect.com/science/article/pii/S2590157524010137 |
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