Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam
Background Hand, foot, and mouth disease (HFMD) is a contagious viral illness caused by enteroviruses, potentially leading to severe complications like encephalitis, myocarditis, and acute pulmonary edema.Objective This study examines clinical features and risk factors for HFMD severity.Materials an...
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Taylor & Francis Group
2025-12-01
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| Series: | International Journal of Adolescence and Youth |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02673843.2025.2528347 |
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| author | Thi Van Vo Phuong Minh Nguyen Hau Trung Tran Tran Huynh Ngoc Thai Quang Chi Ngo Dien Tri Lu Hung Huynh Vinh Ly Trinh Nguyen Ngoc Luu |
| author_facet | Thi Van Vo Phuong Minh Nguyen Hau Trung Tran Tran Huynh Ngoc Thai Quang Chi Ngo Dien Tri Lu Hung Huynh Vinh Ly Trinh Nguyen Ngoc Luu |
| author_sort | Thi Van Vo |
| collection | DOAJ |
| description | Background Hand, foot, and mouth disease (HFMD) is a contagious viral illness caused by enteroviruses, potentially leading to severe complications like encephalitis, myocarditis, and acute pulmonary edema.Objective This study examines clinical features and risk factors for HFMD severity.Materials and Methods A cross-sectional analysis of 200 children under 16 years.Results Oral ulcers (78.0%) and erythematous rashes (64.0%) as the most common symptoms. High fever (≥39°C), fever lasting over two days, and myoclonus were frequently observed. Notably, 25.5% of cases progressed to severe HFMD during hospitalization. Multivariate logistic regression identified ataxia (OR = 31.645, p = 0.024), tachycardia (OR = 41.882, p < 0.001), and exposure to crowded public places (OR = 3.587, p = 0.046) as key risk factors.Conclusion These findings underscore the need for early detection and targeted interventions to reduce complications and improve outcomes. Strengthened surveillance and preventive measures are crucial in managing HFMD in children effectively. |
| format | Article |
| id | doaj-art-c8ed607086e24a71aed8663609cd8e7e |
| institution | Kabale University |
| issn | 0267-3843 2164-4527 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Adolescence and Youth |
| spelling | doaj-art-c8ed607086e24a71aed8663609cd8e7e2025-08-20T03:29:06ZengTaylor & Francis GroupInternational Journal of Adolescence and Youth0267-38432164-45272025-12-0130110.1080/02673843.2025.2528347Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, VietnamThi Van Vo0Phuong Minh Nguyen1Hau Trung Tran2Tran Huynh Ngoc Thai3Quang Chi Ngo4Dien Tri Lu5Hung Huynh Vinh Ly6Trinh Nguyen Ngoc Luu7Department of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamDepartment of Pediatric, Can Tho University of Medicine and Pharmacy, Can Tho city, VietnamBackground Hand, foot, and mouth disease (HFMD) is a contagious viral illness caused by enteroviruses, potentially leading to severe complications like encephalitis, myocarditis, and acute pulmonary edema.Objective This study examines clinical features and risk factors for HFMD severity.Materials and Methods A cross-sectional analysis of 200 children under 16 years.Results Oral ulcers (78.0%) and erythematous rashes (64.0%) as the most common symptoms. High fever (≥39°C), fever lasting over two days, and myoclonus were frequently observed. Notably, 25.5% of cases progressed to severe HFMD during hospitalization. Multivariate logistic regression identified ataxia (OR = 31.645, p = 0.024), tachycardia (OR = 41.882, p < 0.001), and exposure to crowded public places (OR = 3.587, p = 0.046) as key risk factors.Conclusion These findings underscore the need for early detection and targeted interventions to reduce complications and improve outcomes. Strengthened surveillance and preventive measures are crucial in managing HFMD in children effectively.https://www.tandfonline.com/doi/10.1080/02673843.2025.2528347Clinical symptomshand, foot, and mouth disease (HFMD)associated factorsdisease severity predictorsMekong DeltaVietnam |
| spellingShingle | Thi Van Vo Phuong Minh Nguyen Hau Trung Tran Tran Huynh Ngoc Thai Quang Chi Ngo Dien Tri Lu Hung Huynh Vinh Ly Trinh Nguyen Ngoc Luu Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam International Journal of Adolescence and Youth Clinical symptoms hand, foot, and mouth disease (HFMD) associated factors disease severity predictors Mekong Delta Vietnam |
| title | Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam |
| title_full | Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam |
| title_fullStr | Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam |
| title_full_unstemmed | Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam |
| title_short | Clinical characteristics and factors associated with the severity of hand, foot, and mouth disease in Mekong Delta, Vietnam |
| title_sort | clinical characteristics and factors associated with the severity of hand foot and mouth disease in mekong delta vietnam |
| topic | Clinical symptoms hand, foot, and mouth disease (HFMD) associated factors disease severity predictors Mekong Delta Vietnam |
| url | https://www.tandfonline.com/doi/10.1080/02673843.2025.2528347 |
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