Cytotoxic lymphocytes induced by engineered human dendritic cells mediate potent anti-leukemia activity

Cytotoxic lymphocytes induced by engineered human dendritic cells mediate potent anti-leukemia activity

Abstract Effective treatment of acute myeloid leukemia (AML) remains an urgent unmet need. Adoptive transfer of cytotoxic T cells (CTLs) against leukemia-associated antigen (LAA) has strong potential to improve AML treatment. However, the clinical translation of this therapeutic modality is hindered...

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Bibliographic Details
Main Authors: Chenchen Zhao, Bei Jia, Yixing Jiang, Hiroko Shike, Charyguly Annageldiyev, Joseph Cioccio, Kentaro Minagawa, Shin Mineishi, WChristopher Ehmann, Todd D. Schell, Hua Cheng, Hong Zheng
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Cancer Immunology, Immunotherapy
Subjects:
AML
Post-transplant relapse
Cytotoxic lymphocytes
Dendritic cell
Online Access:https://doi.org/10.1007/s00262-025-03971-y
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