Lyophilized human platelet lysate: manufacturing, quality control, and application

Lyophilized human platelet lysate: manufacturing, quality control, and application

BackgroundA significant number of platelet concentrates (PCs) is discarded daily in blood banks due to limited shelf life. Human platelet lysate (HPL), derived from expired PCs, has gained attention as an ethical and sustainable cell culture media supplement in biomedical research and cell therapy p...

Full description

Saved in:

Bibliographic Details
Main Authors:	Kerstin Wendland, Lea Koblin, Dirk Stobbe, Anna Dahms, Debora Singer, Sander Bekeschus, Jan Wesche, Janosch Schoon, Konstanze Aurich
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	human platelet lysate freeze drying lyophilization mesenchymal stromal cells sustainable cell culture HPL
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1513444/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Potential Effect of Human Platelet Lysate on in vitro Expansion of Human Corneal Endothelial Cells Compared with Y-27632 ROCK Inhibitor
by: Mohammad Amir Mishan, et al.
Published: (2021-07-01)

Calcium Chloride vs. Mechanical Preparation of Fibrinogen-Depleted Human Platelet Lysate: Implications for Umbilical Cord Mesenchymal Stem Cell Culture
by: Yen Theng Lim, et al.
Published: (2024-12-01)

Development of a human tyrosinase activity inhibition assay using human melanoma cell lysate
by: Gengxuan Shi, et al.
Published: (2024-11-01)

The therapeutic potential of bacterial lysates: applications and future perspectives
by: Diana Mihaela Alexandru, et al.
Published: (2024-12-01)

IMMUNOMODULATORY ACTIVITY OF THE LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS LB 86 ENZYME LYSATE
by: L. Lаzarenko, et al.
Published: (2024-05-01)

Human platelet lysate: a potential therapeutic for intracerebral hemorrhage
by: Dachang Qiu, et al.
Published: (2025-01-01)

Lyophilization of ASFV vaccine candidate ASFV-G-ΔI177L offers long term stability
by: Nallely Espinoza, et al.
Published: (2024-12-01)

Development and Characterization of Lyophilized Chondroitin Sulfate-Loaded Solid Lipid Nanoparticles: Encapsulation Efficiency and Stability
by: Marta E. Bustos Araya, et al.
Published: (2025-01-01)

Assessment of Quality and Aroma Characteristics of Kefir Produced by Using Grain and Lyophilized Culture
by: Yonca Yuceer, et al.
Published: (2021-09-01)

Peer review of the pesticide risk assessment of the active substance lysate of Willaertia magna C2c Maky
by: European Food Safety Authority (EFSA), et al.
Published: (2025-01-01)

Thymic Stromal-Cell Abnormalities and Dysregulated T-Cell Development in IL-2-Deficient Mice
by: Tannishtha Reya, et al.
Published: (1998-01-01)

Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage
by: Alan B. Dogan, et al.
Published: (2025-01-01)

Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard
by: Roma Fraser, et al.
Published: (2025-02-01)

Immune responses of cattle vaccinated by various routes with Mycobacterium bovis Bacillus Calmette-Guérin (BCG)
by: Mitchell V. Palmer, et al.
Published: (2025-01-01)

Exploring perinatal mesenchymal stromal cells as a potential therapeutic strategy for rheumatoid arthritis
by: Stefano Alivernini, et al.
Published: (2025-01-01)

Cell culture expansion media choice affects secretory, protective and immuno-modulatory features of adipose mesenchymal stromal cell-derived secretomes for orthopaedic applications
by: Enrico Ragni, et al.
Published: (2025-03-01)

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
by: Aliosha I. Figueroa-Valdés, et al.
Published: (2025-01-01)

Chitosan-DNA nanoparticles: synthesis and optimization for long-term storage and effective delivery
by: Aigul Raimbekova, et al.
Published: (2025-01-01)

Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment
by: Wu S, et al.
Published: (2025-02-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

Editorial: Perivascular niche and stem cell signaling in tooth
by: Takehito Ouchi, et al.
Published: (2025-01-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis
by: Damien Veret, et al.
Published: (2025-01-01)

Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity
by: Yuanquan Dai, et al.
Published: (2025-01-01)

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
by: Nicola Alessio, et al.
Published: (2020-03-01)

Enhancing water solubility of phytosterols through Co-amorphization with food-grade coformers
by: Yuxin Li, et al.
Published: (2025-01-01)

Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction
by: Fang Lyu, et al.
Published: (2025-01-01)

Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress
by: Masoumeh Nouri, et al.
Published: (2024-09-01)

The perspectives of autologous hepatocytes generation for the treatment of liver failure
by: M. N. Evseeva, et al.
Published: (2015-12-01)

Purification of mesenchymal stromal cell‐derived small extracellular vesicles using ultrafiltration
by: Rui Lei, et al.
Published: (2025-01-01)

Biosynthetic pathway for leukotrienes is stimulated by lipopolysaccharide and cytokines in pig endometrial stromal cells
by: Barbara Jana, et al.
Published: (2025-01-01)

Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells
by: Melanie Giesen, et al.
Published: (2025-01-01)

Results of biochemical and histological studies after restoration of bone defects using cellular technologies in dental patients
by: А.V. Bambuliak, et al.
Published: (2024-06-01)

Investigation of design space for freeze-drying injectable ibuprofen using response surface methodology
by: Preskar Maja, et al.
Published: (2021-03-01)

Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures
by: Maria C. Arango, et al.
Published: (2025-01-01)

cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro
by: G. Bug, et al.
Published: (1998-01-01)

Inhibitory effects of estetrol on the invasion and migration of immortalized human endometrial stromal cells
by: Akihiko Wakatsuki, et al.
Published: (2024-02-01)

Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Skin Matrix Synthesis and Pigmentation
by: Kee LT, et al.
Published: (2025-02-01)

Mesenchymal stromal cell exosomes for drug delivery of prostate cancer treatments: a review
by: Chengran Wang, et al.
Published: (2025-01-01)