Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia
A 28-year-old Caucasian male with Hashimoto’s disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8697493 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473405488726016 |
|---|---|
| author | G. F. Cittolin-Santos S. Khalil J. K. Bakos K. Baker |
| author_facet | G. F. Cittolin-Santos S. Khalil J. K. Bakos K. Baker |
| author_sort | G. F. Cittolin-Santos |
| collection | DOAJ |
| description | A 28-year-old Caucasian male with Hashimoto’s disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Parietal cell and intrinsic factor antibodies were negative, and he then underwent an esophagogastroduodenoscopy with biopsy. The biopsy was negative for Helicobacter pylori, and the immunohistochemical stains were suggestive of chronic atrophic gastritis. He was started on vitamin B12 1,000 mcg intramuscular injections daily. His hemoglobin, LDH, and haptoglobin normalized. Given the absence of the parietal cell antibody and intrinsic factor antibody, this is a rare case of seronegative pernicious anemia. |
| format | Article |
| id | doaj-art-c8de1cb97e894f949db3c379e6f77063 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-c8de1cb97e894f949db3c379e6f770632025-08-20T03:24:08ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/86974938697493Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic AnemiaG. F. Cittolin-Santos0S. Khalil1J. K. Bakos2K. Baker3Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USAMedical University of South Carolina, Department of Internal Medicine, Charleston, SC, USAMedical University of South Carolina, Department of Internal Medicine, Charleston, SC, USAMedical University of South Carolina, Department of Internal Medicine, Charleston, SC, USAA 28-year-old Caucasian male with Hashimoto’s disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Parietal cell and intrinsic factor antibodies were negative, and he then underwent an esophagogastroduodenoscopy with biopsy. The biopsy was negative for Helicobacter pylori, and the immunohistochemical stains were suggestive of chronic atrophic gastritis. He was started on vitamin B12 1,000 mcg intramuscular injections daily. His hemoglobin, LDH, and haptoglobin normalized. Given the absence of the parietal cell antibody and intrinsic factor antibody, this is a rare case of seronegative pernicious anemia.http://dx.doi.org/10.1155/2020/8697493 |
| spellingShingle | G. F. Cittolin-Santos S. Khalil J. K. Bakos K. Baker Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia Case Reports in Hematology |
| title | Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia |
| title_full | Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia |
| title_fullStr | Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia |
| title_full_unstemmed | Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia |
| title_short | Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia |
| title_sort | chronic atrophic gastritis with negative intrinsic factor and parietal cell antibody presenting as a severe hemolytic anemia |
| url | http://dx.doi.org/10.1155/2020/8697493 |
| work_keys_str_mv | AT gfcittolinsantos chronicatrophicgastritiswithnegativeintrinsicfactorandparietalcellantibodypresentingasaseverehemolyticanemia AT skhalil chronicatrophicgastritiswithnegativeintrinsicfactorandparietalcellantibodypresentingasaseverehemolyticanemia AT jkbakos chronicatrophicgastritiswithnegativeintrinsicfactorandparietalcellantibodypresentingasaseverehemolyticanemia AT kbaker chronicatrophicgastritiswithnegativeintrinsicfactorandparietalcellantibodypresentingasaseverehemolyticanemia |