Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination
The use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic indices, bacteriemia...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/437 |
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| author | V. M. Frolov N. A. Peresadin R. B. Chkhetiany O. V. Kruglova |
| author_facet | V. M. Frolov N. A. Peresadin R. B. Chkhetiany O. V. Kruglova |
| author_sort | V. M. Frolov |
| collection | DOAJ |
| description | The use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic indices, bacteriemia eradication and reduction of the cytokine blood profile - normal serum levels of proinflammatory (IL-13, IL-2, IL-6 and TNF-α) and antiinflammatory (IL-4) cytokines. The findings allowed to considered the use of the reamberin and cycloferon combination in the treatment of patients with CS pathogenetically reasonable and clinically perspective for increasing the antibacterial therapy efficacy. |
| format | Article |
| id | doaj-art-c8dc85069ed64dd0a0bc51c8c4f80b6c |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-c8dc85069ed64dd0a0bc51c8c4f80b6c2025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01575-61827436Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin CombinationV. M. Frolov0N. A. Peresadin1R. B. Chkhetiany2O. V. Kruglova3Lugansk State Medical UniversityLugansk State Medical UniversityLugansk State Medical UniversityLugansk State Medical UniversityThe use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic indices, bacteriemia eradication and reduction of the cytokine blood profile - normal serum levels of proinflammatory (IL-13, IL-2, IL-6 and TNF-α) and antiinflammatory (IL-4) cytokines. The findings allowed to considered the use of the reamberin and cycloferon combination in the treatment of patients with CS pathogenetically reasonable and clinically perspective for increasing the antibacterial therapy efficacy.https://www.antibiotics-chemotherapy.ru/jour/article/view/437chronic sepsispathogenesisantibacterial therapycytokinescycloferonreamberin |
| spellingShingle | V. M. Frolov N. A. Peresadin R. B. Chkhetiany O. V. Kruglova Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination Антибиотики и Химиотерапия chronic sepsis pathogenesis antibacterial therapy cytokines cycloferon reamberin |
| title | Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination |
| title_full | Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination |
| title_fullStr | Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination |
| title_full_unstemmed | Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination |
| title_short | Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination |
| title_sort | increase of antibacterial therapy efficacy in chronic sepsis with cycloferon and reamberin combination |
| topic | chronic sepsis pathogenesis antibacterial therapy cytokines cycloferon reamberin |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/437 |
| work_keys_str_mv | AT vmfrolov increaseofantibacterialtherapyefficacyinchronicsepsiswithcycloferonandreamberincombination AT naperesadin increaseofantibacterialtherapyefficacyinchronicsepsiswithcycloferonandreamberincombination AT rbchkhetiany increaseofantibacterialtherapyefficacyinchronicsepsiswithcycloferonandreamberincombination AT ovkruglova increaseofantibacterialtherapyefficacyinchronicsepsiswithcycloferonandreamberincombination |