Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit.
<h4>Background</h4>The incidence and mortality of sepsis in the intensive care unit (ICU) remain persistently high. This study primarily investigates the risk factors associated with the 90-day mortality in sepsis patients.<h4>Method</h4>This retrospective study included 123...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0325813 |
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| author | Yuntian Xu He Zhang Jiezhi Li Nan Wang Huifeng Yuan |
| author_facet | Yuntian Xu He Zhang Jiezhi Li Nan Wang Huifeng Yuan |
| author_sort | Yuntian Xu |
| collection | DOAJ |
| description | <h4>Background</h4>The incidence and mortality of sepsis in the intensive care unit (ICU) remain persistently high. This study primarily investigates the risk factors associated with the 90-day mortality in sepsis patients.<h4>Method</h4>This retrospective study included 123 sepsis patients admitted to a hospital in China from January 2015 to December 2018, clinical and abdominal CT data were compared between survivors and non-survivors, logistic regression and Cox regression analyses were performed on the abdominal CT data, Finally, survival curves for different skeletal muscle indices were analyzed using the Kaplan-Meier (K-M) method.<h4>Result</h4>In the abdominal CT scan data, significant differences were observed between survivors and non-survivors in skeletal muscle density (SMD), skeletal muscle area (SMA), skeletal muscle index (SMI), and subcutaneous adipose tissue area (SAT); Cox regression analysis revealed that higher skeletal muscle density (SMD) (HR = 0.953; 95% CI = 0.923-0.984; p = 0.003), skeletal muscle area (SMA) (HR = 0.986; 95% CI = 0.976-0.997; p = 0.011), and skeletal muscle index (SMI) (HR = 0.951; 95% CI = 0.917-0.985; p = 0.005) were significantly associated with lower 90-day mortality compared to non-survivors. Finally, the Kaplan-Meier (K-M) curves demonstrated differences in survival based on the median skeletal muscle index (SMI).<h4>Conclusion</h4>Body composition parameters assessed by abdominal CT scans are highly associated with 90-day mortality in ICU patients with sepsis. Among them, SMD, SMA, and SMI are valuable prognostic factors. |
| format | Article |
| id | doaj-art-c8d43d93b76c470ebee2d6cb0715ba07 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c8d43d93b76c470ebee2d6cb0715ba072025-08-20T03:26:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032581310.1371/journal.pone.0325813Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit.Yuntian XuHe ZhangJiezhi LiNan WangHuifeng Yuan<h4>Background</h4>The incidence and mortality of sepsis in the intensive care unit (ICU) remain persistently high. This study primarily investigates the risk factors associated with the 90-day mortality in sepsis patients.<h4>Method</h4>This retrospective study included 123 sepsis patients admitted to a hospital in China from January 2015 to December 2018, clinical and abdominal CT data were compared between survivors and non-survivors, logistic regression and Cox regression analyses were performed on the abdominal CT data, Finally, survival curves for different skeletal muscle indices were analyzed using the Kaplan-Meier (K-M) method.<h4>Result</h4>In the abdominal CT scan data, significant differences were observed between survivors and non-survivors in skeletal muscle density (SMD), skeletal muscle area (SMA), skeletal muscle index (SMI), and subcutaneous adipose tissue area (SAT); Cox regression analysis revealed that higher skeletal muscle density (SMD) (HR = 0.953; 95% CI = 0.923-0.984; p = 0.003), skeletal muscle area (SMA) (HR = 0.986; 95% CI = 0.976-0.997; p = 0.011), and skeletal muscle index (SMI) (HR = 0.951; 95% CI = 0.917-0.985; p = 0.005) were significantly associated with lower 90-day mortality compared to non-survivors. Finally, the Kaplan-Meier (K-M) curves demonstrated differences in survival based on the median skeletal muscle index (SMI).<h4>Conclusion</h4>Body composition parameters assessed by abdominal CT scans are highly associated with 90-day mortality in ICU patients with sepsis. Among them, SMD, SMA, and SMI are valuable prognostic factors.https://doi.org/10.1371/journal.pone.0325813 |
| spellingShingle | Yuntian Xu He Zhang Jiezhi Li Nan Wang Huifeng Yuan Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit. PLoS ONE |
| title | Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit. |
| title_full | Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit. |
| title_fullStr | Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit. |
| title_full_unstemmed | Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit. |
| title_short | Risk factors analysis of 90-day mortality in patients with sepsis in intensive care unit. |
| title_sort | risk factors analysis of 90 day mortality in patients with sepsis in intensive care unit |
| url | https://doi.org/10.1371/journal.pone.0325813 |
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