Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses
This paper studies the antidiabetic effects of soluble dietary fiber (SDF) from steam explosion-modified black soybean hull in low-dose streptozotocin- (STZ-) induced type 2 diabetic mouses. Male C57/BL6 mouses were divided into 4 groups: control (nondiabetic, no SDF intake), model (diabetes only),...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/6821438 |
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| author | Meng Shen Weihao Wang Yunfei Ge Ziyue Kang Juan Wang Zhigang Quan Jinling Xiao Longkui Cao |
| author_facet | Meng Shen Weihao Wang Yunfei Ge Ziyue Kang Juan Wang Zhigang Quan Jinling Xiao Longkui Cao |
| author_sort | Meng Shen |
| collection | DOAJ |
| description | This paper studies the antidiabetic effects of soluble dietary fiber (SDF) from steam explosion-modified black soybean hull in low-dose streptozotocin- (STZ-) induced type 2 diabetic mouses. Male C57/BL6 mouses were divided into 4 groups: control (nondiabetic, no SDF intake), model (diabetes only), metformin (metformin: 100 mg/kg body weight), and SDF (SDF: 600 mg/kg body weight). Four weeks post-SDF treatment, treatment of SDF decreased the weight gain of diabetic mouses, normalised the blood glucose level, and reduced the serum cholesterol, serum insulin, leptin, glucagon-like peptide, total cholesterol, triglyceride, low-density lipoprotein cholesterol, arteriosclerosis index, aspartate aminotransferase activity, and malondialdehyde. It also increased high-density lipoprotein cholesterol, adiponectin, glycopeptide peroxidase, superoxide dismutase activity and repaired the pancreatic injury of the diabetic mouses. Our research results show that SDF has the potential for use in type 2 diabetes treatment. |
| format | Article |
| id | doaj-art-c8d2c4b1f50f4d589a3385c43a68a123 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c8d2c4b1f50f4d589a3385c43a68a1232025-08-20T03:24:11ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/68214386821438Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic MousesMeng Shen0Weihao Wang1Yunfei Ge2Ziyue Kang3Juan Wang4Zhigang Quan5Jinling Xiao6Longkui Cao7College of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaCollege of Food Science, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, ChinaThis paper studies the antidiabetic effects of soluble dietary fiber (SDF) from steam explosion-modified black soybean hull in low-dose streptozotocin- (STZ-) induced type 2 diabetic mouses. Male C57/BL6 mouses were divided into 4 groups: control (nondiabetic, no SDF intake), model (diabetes only), metformin (metformin: 100 mg/kg body weight), and SDF (SDF: 600 mg/kg body weight). Four weeks post-SDF treatment, treatment of SDF decreased the weight gain of diabetic mouses, normalised the blood glucose level, and reduced the serum cholesterol, serum insulin, leptin, glucagon-like peptide, total cholesterol, triglyceride, low-density lipoprotein cholesterol, arteriosclerosis index, aspartate aminotransferase activity, and malondialdehyde. It also increased high-density lipoprotein cholesterol, adiponectin, glycopeptide peroxidase, superoxide dismutase activity and repaired the pancreatic injury of the diabetic mouses. Our research results show that SDF has the potential for use in type 2 diabetes treatment.http://dx.doi.org/10.1155/2019/6821438 |
| spellingShingle | Meng Shen Weihao Wang Yunfei Ge Ziyue Kang Juan Wang Zhigang Quan Jinling Xiao Longkui Cao Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses Journal of Chemistry |
| title | Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses |
| title_full | Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses |
| title_fullStr | Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses |
| title_full_unstemmed | Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses |
| title_short | Antidiabetic Effects of Soluble Dietary Fiber from Steam Explosion-Modified Black Soybean Hull in Low-Dose Streptozotocin-Induced Type 2 Diabetic Mouses |
| title_sort | antidiabetic effects of soluble dietary fiber from steam explosion modified black soybean hull in low dose streptozotocin induced type 2 diabetic mouses |
| url | http://dx.doi.org/10.1155/2019/6821438 |
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