Gut microbiota has the potential to improve health of menopausal women by regulating estrogen
Menopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women’s health. The symptoms related to menopause are related to the imbalance of gut microbiota. Studies have shown that the diversity of gu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1562332/full |
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| author | Haiqiang Wang Fan Shi Lihong Zheng Wenhui Zhou Bowen Mi Siyu Wu Xiaoling Feng |
| author_facet | Haiqiang Wang Fan Shi Lihong Zheng Wenhui Zhou Bowen Mi Siyu Wu Xiaoling Feng |
| author_sort | Haiqiang Wang |
| collection | DOAJ |
| description | Menopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women’s health. The symptoms related to menopause are related to the imbalance of gut microbiota. Studies have shown that the diversity of gut microbiota after menopause is lower than that before menopause, and the weakening of microbial decomposition will lead to the decrease of circulating estrogen, gradually resulting in disorders of lipid metabolism, cognitive decline, osteoporosis and other diseases. Gut microbiota play a key role in regulating estrogen levels. By secreting β-glucuronidase, it increases the reabsorption of estrogen in the enterohepatic circulation and mediates phytoestrogen metabolism, regulates estrogen homeostasis in the host and affects disease development and prognosis. Therefore, the gut microbiota is an overall regulator of women’s estrogen status during menopause and an untapped new area for improving women’s postmenopausal health. Changing the gut microbiota through specific prebiotics, probiotics, etc., and then affecting estrogen levels provides exciting opportunities for future therapeutic applications. |
| format | Article |
| id | doaj-art-c8d2970f31924099a3a64c1a9c66d072 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-c8d2970f31924099a3a64c1a9c66d0722025-08-20T03:11:14ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15623321562332Gut microbiota has the potential to improve health of menopausal women by regulating estrogenHaiqiang Wang0Fan Shi1Lihong Zheng2Wenhui Zhou3Bowen Mi4Siyu Wu5Xiaoling Feng6Department of Internal Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Internal Medicine, Fourth Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Gynecology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaMenopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women’s health. The symptoms related to menopause are related to the imbalance of gut microbiota. Studies have shown that the diversity of gut microbiota after menopause is lower than that before menopause, and the weakening of microbial decomposition will lead to the decrease of circulating estrogen, gradually resulting in disorders of lipid metabolism, cognitive decline, osteoporosis and other diseases. Gut microbiota play a key role in regulating estrogen levels. By secreting β-glucuronidase, it increases the reabsorption of estrogen in the enterohepatic circulation and mediates phytoestrogen metabolism, regulates estrogen homeostasis in the host and affects disease development and prognosis. Therefore, the gut microbiota is an overall regulator of women’s estrogen status during menopause and an untapped new area for improving women’s postmenopausal health. Changing the gut microbiota through specific prebiotics, probiotics, etc., and then affecting estrogen levels provides exciting opportunities for future therapeutic applications.https://www.frontiersin.org/articles/10.3389/fendo.2025.1562332/fullgut microbiotamenopauseestrogenlipid metabolism disordercognition impairmentclinical application |
| spellingShingle | Haiqiang Wang Fan Shi Lihong Zheng Wenhui Zhou Bowen Mi Siyu Wu Xiaoling Feng Gut microbiota has the potential to improve health of menopausal women by regulating estrogen Frontiers in Endocrinology gut microbiota menopause estrogen lipid metabolism disorder cognition impairment clinical application |
| title | Gut microbiota has the potential to improve health of menopausal women by regulating estrogen |
| title_full | Gut microbiota has the potential to improve health of menopausal women by regulating estrogen |
| title_fullStr | Gut microbiota has the potential to improve health of menopausal women by regulating estrogen |
| title_full_unstemmed | Gut microbiota has the potential to improve health of menopausal women by regulating estrogen |
| title_short | Gut microbiota has the potential to improve health of menopausal women by regulating estrogen |
| title_sort | gut microbiota has the potential to improve health of menopausal women by regulating estrogen |
| topic | gut microbiota menopause estrogen lipid metabolism disorder cognition impairment clinical application |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1562332/full |
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