Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

ABSTRACT The gliotransmitter adenosine 5'‐triphosphate (ATP) and its enzymatic degradation product adenosine play a major role in orchestrating in the hippocampus cognitive and affective functions via P2 purinoceptors (P2X, P2Y) and P1 adenosine receptors (A1, A2A). Although numerous reviews ex...

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Bibliographic Details
Main Authors: Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:MedComm
Subjects:
A2A receptors
adenosine
astrocytic ATP
cognitive disorders
depressive‐like behavior
P2X receptors
Online Access:https://doi.org/10.1002/mco2.70177
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