G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo

G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo

Abstract Disease progression and drug resistance in patients with chronic lymphocytic leukaemia (CLL) depend on signals from the tumour microenvironment in lymphoid sites. GRK2 inhibits the egress of normal B cells from lymphoid tissues by inducing the downregulation of the S1P-receptor 1 (S1PR1). I...

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Main Authors: María Chiara Cassarino, Ana Colado, Valeria Sarapura Martinez, Claudio Martines, Alice Bonato, Martin Bertini, Miguel Pavlovksy, Rosario Custidiano, Fernando Raimundo Bezares, Pablo Elías Morande, Mónica Vermeulen, Romina Gamberale, Mirta Giordano, Dimitar G Efremov, Mercedes Borge
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-91536-5
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