Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model
Abstract Background Colorectal cancer (CRC) development is influenced by both iron and gut microbiota composition. While iron supplementation is routinely used to manage anemia in CRC patients, it may also impact gut microbiota and promote tumorigenesis. In this study, we investigated the impact of...
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BMC
2025-04-01
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| Online Access: | https://doi.org/10.1186/s40168-025-02101-1 |
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| author | Thibault Cuisiniere Roy Hajjar Manon Oliero Annie Calvé Gabriela Fragoso Hervé Vennin Rendos Claire Gerkins Nassima Taleb Marianne Gagnon-Konamna François Dagbert Rasmy Loungnarath Herawaty Sebajang Frank Schwenter Ramses Wassef Richard Ratelle Éric De Broux Carole Richard Manuela M. Santos |
| author_facet | Thibault Cuisiniere Roy Hajjar Manon Oliero Annie Calvé Gabriela Fragoso Hervé Vennin Rendos Claire Gerkins Nassima Taleb Marianne Gagnon-Konamna François Dagbert Rasmy Loungnarath Herawaty Sebajang Frank Schwenter Ramses Wassef Richard Ratelle Éric De Broux Carole Richard Manuela M. Santos |
| author_sort | Thibault Cuisiniere |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) development is influenced by both iron and gut microbiota composition. While iron supplementation is routinely used to manage anemia in CRC patients, it may also impact gut microbiota and promote tumorigenesis. In this study, we investigated the impact of initial gut microbiota composition on iron-promoted tumorigenesis. We performed fecal microbiota transplantation (FMT) in Apc Min/+ mice using samples from healthy controls, CRC patients, and mice, followed by exposure to iron sufficient or iron excess diets. Results We found that iron supplementation promoted CRC and resulted in distinct gut microbiota changes in Apc Min/+ mice receiving FMT from CRC patients (FMT-CRC), but not from healthy controls or mice. Oral treatment with identified bacterial strains, namely Faecalibaculum rodentium, Holdemanella biformis, Bifidobacterium pseudolongum, and Alistipes inops, protected FMT-CRC mice against iron-promoted tumorigenesis. Conclusions Our findings suggest that microbiota-targeted interventions may mitigate tumorigenic effects of iron supplementation in anemic patients with CRC. Graphical Abstract Video Abstract |
| format | Article |
| id | doaj-art-c8cc00950da2401eac14de3d76ebc600 |
| institution | OA Journals |
| issn | 2049-2618 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj-art-c8cc00950da2401eac14de3d76ebc6002025-08-20T02:30:24ZengBMCMicrobiome2049-26182025-04-0113111610.1186/s40168-025-02101-1Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine modelThibault Cuisiniere0Roy Hajjar1Manon Oliero2Annie Calvé3Gabriela Fragoso4Hervé Vennin Rendos5Claire Gerkins6Nassima Taleb7Marianne Gagnon-Konamna8François Dagbert9Rasmy Loungnarath10Herawaty Sebajang11Frank Schwenter12Ramses Wassef13Richard Ratelle14Éric De Broux15Carole Richard16Manuela M. Santos17Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Digestive Surgery Service, Centre Hospitalier de L’Université de Montréal (CHUM)Nutrition and Microbiome Laboratory, Centre de Recherche du Centre hospitalier de l’, Université de Montréal (CRCHUM)Abstract Background Colorectal cancer (CRC) development is influenced by both iron and gut microbiota composition. While iron supplementation is routinely used to manage anemia in CRC patients, it may also impact gut microbiota and promote tumorigenesis. In this study, we investigated the impact of initial gut microbiota composition on iron-promoted tumorigenesis. We performed fecal microbiota transplantation (FMT) in Apc Min/+ mice using samples from healthy controls, CRC patients, and mice, followed by exposure to iron sufficient or iron excess diets. Results We found that iron supplementation promoted CRC and resulted in distinct gut microbiota changes in Apc Min/+ mice receiving FMT from CRC patients (FMT-CRC), but not from healthy controls or mice. Oral treatment with identified bacterial strains, namely Faecalibaculum rodentium, Holdemanella biformis, Bifidobacterium pseudolongum, and Alistipes inops, protected FMT-CRC mice against iron-promoted tumorigenesis. Conclusions Our findings suggest that microbiota-targeted interventions may mitigate tumorigenic effects of iron supplementation in anemic patients with CRC. Graphical Abstract Video Abstracthttps://doi.org/10.1186/s40168-025-02101-1Colorectal cancerIron supplementationGut microbiota |
| spellingShingle | Thibault Cuisiniere Roy Hajjar Manon Oliero Annie Calvé Gabriela Fragoso Hervé Vennin Rendos Claire Gerkins Nassima Taleb Marianne Gagnon-Konamna François Dagbert Rasmy Loungnarath Herawaty Sebajang Frank Schwenter Ramses Wassef Richard Ratelle Éric De Broux Carole Richard Manuela M. Santos Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model Microbiome Colorectal cancer Iron supplementation Gut microbiota |
| title | Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model |
| title_full | Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model |
| title_fullStr | Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model |
| title_full_unstemmed | Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model |
| title_short | Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model |
| title_sort | initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation evidence from a murine model |
| topic | Colorectal cancer Iron supplementation Gut microbiota |
| url | https://doi.org/10.1186/s40168-025-02101-1 |
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