Comprehensive Management of Upper Tract Urothelial Carcinoma
Urothelial carcinoma of the upper urinary tract represents only 5% of all urothelial cancers. The 5-year cancer-specific survival in the United States is roughly 75% with grade and stage being the most powerful predictors of survival. Nephroureterectomy with excision of the ipsilateral ureteral orif...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2009/656521 |
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| author | Georgios Koukourakis Georgios Zacharias Michael Koukourakis Kiriaki Pistevou-Gobaki Christos Papaloukas Athanasios Kostakopoulos Vassilios Kouloulias |
| author_facet | Georgios Koukourakis Georgios Zacharias Michael Koukourakis Kiriaki Pistevou-Gobaki Christos Papaloukas Athanasios Kostakopoulos Vassilios Kouloulias |
| author_sort | Georgios Koukourakis |
| collection | DOAJ |
| description | Urothelial carcinoma of the upper urinary tract represents only 5% of all urothelial cancers. The 5-year cancer-specific survival in the United States is roughly 75% with grade and stage being the most powerful predictors of survival. Nephroureterectomy with excision of the ipsilateral ureteral orifice and bladder cuff en bloc remains the gold standard treatment of the upper urinary tract urothelial cancers, while endoscopic and laparoscopic approaches are rapidly evolving as reasonable alternatives of care depending on grade and stage of disease. Several controversies remain in their management, including a selection of endoscopic versus laparoscopic approaches, management strategies on the distal ureter, the role of lymphadenectomy, and the value of chemotherapy in upper tract disease. Aims of this paper are to critically review the management of such tumors, including endoscopic management, laparoscopic nephroureterectomy and management of the distal ureter, the role of lymphadenectomy, and the emerging role of chemotherapy in their treatment. |
| format | Article |
| id | doaj-art-c8cb65dbd7174f459a24ad54606f766b |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-c8cb65dbd7174f459a24ad54606f766b2025-02-03T05:58:45ZengWileyAdvances in Urology1687-63691687-63772009-01-01200910.1155/2009/656521656521Comprehensive Management of Upper Tract Urothelial CarcinomaGeorgios Koukourakis0Georgios Zacharias1Michael Koukourakis2Kiriaki Pistevou-Gobaki3Christos Papaloukas4Athanasios Kostakopoulos5Vassilios Kouloulias6Radiation Therapy Unit, 2nd Department of Radiology, Athens University Medical School, Attikon University Hospital, Rimini 1 Street, Haidari, 12462 Athens , GreeceSection of Pathology, Policlinic of Athens, Piraeus 5 Street, 11474 Athens, GreeceRadiation Therapy Unit, University Hospital of Thrace, 68100 Alexandroupolis, GreeceRadiation-Oncology Department, AHEPA University Hospital of Thessalonica, 54301 Thessalonica, GreeceRadiation-Oncology Department, AHEPA University Hospital of Thessalonica, 54301 Thessalonica, GreeceSection of Urology, University Hospital of Athens, 10029 Athens, GreeceRadiation Therapy Unit, 2nd Department of Radiology, Athens University Medical School, Attikon University Hospital, Rimini 1 Street, Haidari, 12462 Athens , GreeceUrothelial carcinoma of the upper urinary tract represents only 5% of all urothelial cancers. The 5-year cancer-specific survival in the United States is roughly 75% with grade and stage being the most powerful predictors of survival. Nephroureterectomy with excision of the ipsilateral ureteral orifice and bladder cuff en bloc remains the gold standard treatment of the upper urinary tract urothelial cancers, while endoscopic and laparoscopic approaches are rapidly evolving as reasonable alternatives of care depending on grade and stage of disease. Several controversies remain in their management, including a selection of endoscopic versus laparoscopic approaches, management strategies on the distal ureter, the role of lymphadenectomy, and the value of chemotherapy in upper tract disease. Aims of this paper are to critically review the management of such tumors, including endoscopic management, laparoscopic nephroureterectomy and management of the distal ureter, the role of lymphadenectomy, and the emerging role of chemotherapy in their treatment.http://dx.doi.org/10.1155/2009/656521 |
| spellingShingle | Georgios Koukourakis Georgios Zacharias Michael Koukourakis Kiriaki Pistevou-Gobaki Christos Papaloukas Athanasios Kostakopoulos Vassilios Kouloulias Comprehensive Management of Upper Tract Urothelial Carcinoma Advances in Urology |
| title | Comprehensive Management of Upper Tract Urothelial Carcinoma |
| title_full | Comprehensive Management of Upper Tract Urothelial Carcinoma |
| title_fullStr | Comprehensive Management of Upper Tract Urothelial Carcinoma |
| title_full_unstemmed | Comprehensive Management of Upper Tract Urothelial Carcinoma |
| title_short | Comprehensive Management of Upper Tract Urothelial Carcinoma |
| title_sort | comprehensive management of upper tract urothelial carcinoma |
| url | http://dx.doi.org/10.1155/2009/656521 |
| work_keys_str_mv | AT georgioskoukourakis comprehensivemanagementofuppertracturothelialcarcinoma AT georgioszacharias comprehensivemanagementofuppertracturothelialcarcinoma AT michaelkoukourakis comprehensivemanagementofuppertracturothelialcarcinoma AT kiriakipistevougobaki comprehensivemanagementofuppertracturothelialcarcinoma AT christospapaloukas comprehensivemanagementofuppertracturothelialcarcinoma AT athanasioskostakopoulos comprehensivemanagementofuppertracturothelialcarcinoma AT vassilioskouloulias comprehensivemanagementofuppertracturothelialcarcinoma |