Microneedles at the Forefront of Next Generation Theranostics
Abstract Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic tr...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202412140 |
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| author | Chan Wang Yuan Yang Jiaqi Zhang Hanrui Zhang Qian Wang Shengmei Ma Pengfei Zhao Zhou Li Yuxin Liu |
| author_facet | Chan Wang Yuan Yang Jiaqi Zhang Hanrui Zhang Qian Wang Shengmei Ma Pengfei Zhao Zhou Li Yuxin Liu |
| author_sort | Chan Wang |
| collection | DOAJ |
| description | Abstract Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated diagnostic and therapeutic platforms. Microneedles enhance access to biomarkers via interstitial fluid, enabling real‐time monitoring of physiological conditions, such as glucose and hormone levels, thus facilitating continuous health tracking. The evolution of microneedle design from solid to dissolvable forms broadens their utility from mere drug delivery to complex sensing and therapeutic applications, including insulin delivery for diabetes management, vaccination, and gene therapy. This paper delves into the integration of microneedles with wearable technologies, highlighting their role in closed‐loop systems that combine real‐time monitoring with dynamic, precise therapeutic delivery. By addressing gaps in the literature regarding their integrated diagnostic and treatment capabilities, this review underscores the pivotal role of microneedles in personalizing medicine. It concludes with a visionary perspective on the future trajectory of microneedle technology, emphasizing its potential to revolutionize therapeutic strategies through enhanced efficacy, safety, and patient compliance. |
| format | Article |
| id | doaj-art-c8c716fc2da34695be91fababb7ab8dc |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-c8c716fc2da34695be91fababb7ab8dc2025-08-20T03:29:52ZengWileyAdvanced Science2198-38442025-06-011224n/an/a10.1002/advs.202412140Microneedles at the Forefront of Next Generation TheranosticsChan Wang0Yuan Yang1Jiaqi Zhang2Hanrui Zhang3Qian Wang4Shengmei Ma5Pengfei Zhao6Zhou Li7Yuxin Liu8Department of Biomedical Engineering (BME) National University of Singapore Singapore 117583 SingaporeBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaDepartment of Biomedical Engineering (BME) National University of Singapore Singapore 117583 SingaporeDepartment of Biomedical Engineering (BME) National University of Singapore Singapore 117583 SingaporeDepartment of Biomedical Engineering (BME) National University of Singapore Singapore 117583 SingaporeDepartment of Radiology Beijing Friendship Hospital Capital Medical University No. 95, Yongan Road, Xicheng District Beijing 100050 ChinaDepartment of Radiology Beijing Friendship Hospital Capital Medical University No. 95, Yongan Road, Xicheng District Beijing 100050 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaDepartment of Biomedical Engineering (BME) National University of Singapore Singapore 117583 SingaporeAbstract Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated diagnostic and therapeutic platforms. Microneedles enhance access to biomarkers via interstitial fluid, enabling real‐time monitoring of physiological conditions, such as glucose and hormone levels, thus facilitating continuous health tracking. The evolution of microneedle design from solid to dissolvable forms broadens their utility from mere drug delivery to complex sensing and therapeutic applications, including insulin delivery for diabetes management, vaccination, and gene therapy. This paper delves into the integration of microneedles with wearable technologies, highlighting their role in closed‐loop systems that combine real‐time monitoring with dynamic, precise therapeutic delivery. By addressing gaps in the literature regarding their integrated diagnostic and treatment capabilities, this review underscores the pivotal role of microneedles in personalizing medicine. It concludes with a visionary perspective on the future trajectory of microneedle technology, emphasizing its potential to revolutionize therapeutic strategies through enhanced efficacy, safety, and patient compliance.https://doi.org/10.1002/advs.202412140biomarker monitoringclosed‐loop systemsmicroneedlestheranosticstransdermal drug delivery |
| spellingShingle | Chan Wang Yuan Yang Jiaqi Zhang Hanrui Zhang Qian Wang Shengmei Ma Pengfei Zhao Zhou Li Yuxin Liu Microneedles at the Forefront of Next Generation Theranostics Advanced Science biomarker monitoring closed‐loop systems microneedles theranostics transdermal drug delivery |
| title | Microneedles at the Forefront of Next Generation Theranostics |
| title_full | Microneedles at the Forefront of Next Generation Theranostics |
| title_fullStr | Microneedles at the Forefront of Next Generation Theranostics |
| title_full_unstemmed | Microneedles at the Forefront of Next Generation Theranostics |
| title_short | Microneedles at the Forefront of Next Generation Theranostics |
| title_sort | microneedles at the forefront of next generation theranostics |
| topic | biomarker monitoring closed‐loop systems microneedles theranostics transdermal drug delivery |
| url | https://doi.org/10.1002/advs.202412140 |
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