Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023
In Ethiopia, dengue virus (DENV) infections have been reported in several regions; however, little is known about the genetic diversity of circulating viruses. We conducted clinical surveillance of DENV during the 2023 nationwide outbreak in Ethiopia. We enrolled patients at 3 sentinel hospital sit...
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Centers for Disease Control and Prevention
2025-03-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/3/24-0996_article |
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| author | Adugna Abera Houriiyah Tegally Geremew Tasew Eduan Wilkinson Abraham Ali Feyisa Regasa Molalegne Bitew Mahlet Belachew Lucious Chabuka Gaspary Mwanyika Derek Tshiabuila Jennifer Giandhari Sureshnee Pillay Jenicca Poogavanan Monika Moir Moritz U.G. Kraemer Kamran Khan Carmen Huber Getachew Tollera Tobias F. Rinke de Wit Cheryl Baxter Richard Lessells Dawit Wolday Dereje Beyene Tulio de Oliveira |
| author_facet | Adugna Abera Houriiyah Tegally Geremew Tasew Eduan Wilkinson Abraham Ali Feyisa Regasa Molalegne Bitew Mahlet Belachew Lucious Chabuka Gaspary Mwanyika Derek Tshiabuila Jennifer Giandhari Sureshnee Pillay Jenicca Poogavanan Monika Moir Moritz U.G. Kraemer Kamran Khan Carmen Huber Getachew Tollera Tobias F. Rinke de Wit Cheryl Baxter Richard Lessells Dawit Wolday Dereje Beyene Tulio de Oliveira |
| author_sort | Adugna Abera |
| collection | DOAJ |
| description |
In Ethiopia, dengue virus (DENV) infections have been reported in several regions; however, little is known about the genetic diversity of circulating viruses. We conducted clinical surveillance of DENV during the 2023 nationwide outbreak in Ethiopia. We enrolled patients at 3 sentinel hospital sites. Using reverse transcription PCR, we screened serum samples for 3 arboviruses and then serotyped and whole-genome sequenced DENV-positive samples. We detected DENV-1 and DENV-3 serotypes. Phylogenetic analysis identified 1 transmission cluster for DENV-1 (genotype III major lineage A) and 2 clusters for DENV-3 (genotype III major lineage B). The first DENV-3 cluster was closely related to an isolate from a 2023 dengue outbreak in Italy; the second cluster was related to isolates from India. Co-circulation of DENV-1 and DENV-3 in Ethiopia highlights the potential for severe dengue. Intensified surveillance and coordinated public health responses are needed to address the threat of severe dengue outbreaks.
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| format | Article |
| id | doaj-art-c8c0b048ddbc422199b3d0fe61d3d357 |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-c8c0b048ddbc422199b3d0fe61d3d3572025-08-20T03:16:24ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-03-0131351652510.3201/eid3103.240996Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023Adugna AberaHouriiyah TegallyGeremew TasewEduan WilkinsonAbraham AliFeyisa RegasaMolalegne BitewMahlet BelachewLucious ChabukaGaspary MwanyikaDerek TshiabuilaJennifer GiandhariSureshnee PillayJenicca PoogavananMonika MoirMoritz U.G. KraemerKamran KhanCarmen HuberGetachew TolleraTobias F. Rinke de WitCheryl BaxterRichard LessellsDawit WoldayDereje BeyeneTulio de Oliveira In Ethiopia, dengue virus (DENV) infections have been reported in several regions; however, little is known about the genetic diversity of circulating viruses. We conducted clinical surveillance of DENV during the 2023 nationwide outbreak in Ethiopia. We enrolled patients at 3 sentinel hospital sites. Using reverse transcription PCR, we screened serum samples for 3 arboviruses and then serotyped and whole-genome sequenced DENV-positive samples. We detected DENV-1 and DENV-3 serotypes. Phylogenetic analysis identified 1 transmission cluster for DENV-1 (genotype III major lineage A) and 2 clusters for DENV-3 (genotype III major lineage B). The first DENV-3 cluster was closely related to an isolate from a 2023 dengue outbreak in Italy; the second cluster was related to isolates from India. Co-circulation of DENV-1 and DENV-3 in Ethiopia highlights the potential for severe dengue. Intensified surveillance and coordinated public health responses are needed to address the threat of severe dengue outbreaks. https://wwwnc.cdc.gov/eid/article/31/3/24-0996_articledenguedengue virusDENVserotypegenotypephylogenetic analysis |
| spellingShingle | Adugna Abera Houriiyah Tegally Geremew Tasew Eduan Wilkinson Abraham Ali Feyisa Regasa Molalegne Bitew Mahlet Belachew Lucious Chabuka Gaspary Mwanyika Derek Tshiabuila Jennifer Giandhari Sureshnee Pillay Jenicca Poogavanan Monika Moir Moritz U.G. Kraemer Kamran Khan Carmen Huber Getachew Tollera Tobias F. Rinke de Wit Cheryl Baxter Richard Lessells Dawit Wolday Dereje Beyene Tulio de Oliveira Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 Emerging Infectious Diseases dengue dengue virus DENV serotype genotype phylogenetic analysis |
| title | Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 |
| title_full | Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 |
| title_fullStr | Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 |
| title_full_unstemmed | Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 |
| title_short | Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 |
| title_sort | genomic characterization of circulating dengue virus ethiopia 2022 2023 |
| topic | dengue dengue virus DENV serotype genotype phylogenetic analysis |
| url | https://wwwnc.cdc.gov/eid/article/31/3/24-0996_article |
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