Joint association of air pollutants on cardiometabolic multimorbidity
Abstract We estimated the association between combined exposure to air pollutants and the development of cardiometabolic multimorbidity (CM) and all-cause mortality. An air pollution score was calculated to determine the combined exposure to five air pollutants. CM was defined as the instance of at...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-77886-6 |
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| author | Liang Xia Shan Zhou Liyuan Han Weifeng Sun Hongpeng Sun |
| author_facet | Liang Xia Shan Zhou Liyuan Han Weifeng Sun Hongpeng Sun |
| author_sort | Liang Xia |
| collection | DOAJ |
| description | Abstract We estimated the association between combined exposure to air pollutants and the development of cardiometabolic multimorbidity (CM) and all-cause mortality. An air pollution score was calculated to determine the combined exposure to five air pollutants. CM was defined as the instance of at least two types of diseases. A genetic risk score (GRS) was calculated for each individual. A multistate regression model was used to investigate the effect of the combined associations of air pollutants on each stage of CM progression. After multivariable adjustment, the air pollution score was related with greater susceptibility of CM and all-cause mortality, and those with a high GRS for cardiovascular disease (CVD) or coronary heart disease (CHD) and a high air pollution score had a greater susceptibility of incident CM and all-cause mortality. The multistate model revealed that the greater air pollution score was connected with the susceptibility of progressing from disease-free baseline to having one cardiometabolic disease, and next to CM, and eventually to death. Combined exposure to five air pollutants were related with greater susceptibility of CM and all-cause mortality in a dose-dependent style and is related with the progression of CM and with all-cause mortality. |
| format | Article |
| id | doaj-art-c8b8b16ba7b14c8ca6f389afa2e769d9 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c8b8b16ba7b14c8ca6f389afa2e769d92025-08-20T02:13:55ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-77886-6Joint association of air pollutants on cardiometabolic multimorbidityLiang Xia0Shan Zhou1Liyuan Han2Weifeng Sun3Hongpeng Sun4Department of Gynecology, Ningbo No.2 HospitalDepartment of Endocrinology, Ningbo No.2 HospitalDepartment of Gynecology, Ningbo No.2 HospitalDepartment of Cardiology, Ningbo No. 2 HospitalSchool of Public Health, Medical College of Soochow UniversityAbstract We estimated the association between combined exposure to air pollutants and the development of cardiometabolic multimorbidity (CM) and all-cause mortality. An air pollution score was calculated to determine the combined exposure to five air pollutants. CM was defined as the instance of at least two types of diseases. A genetic risk score (GRS) was calculated for each individual. A multistate regression model was used to investigate the effect of the combined associations of air pollutants on each stage of CM progression. After multivariable adjustment, the air pollution score was related with greater susceptibility of CM and all-cause mortality, and those with a high GRS for cardiovascular disease (CVD) or coronary heart disease (CHD) and a high air pollution score had a greater susceptibility of incident CM and all-cause mortality. The multistate model revealed that the greater air pollution score was connected with the susceptibility of progressing from disease-free baseline to having one cardiometabolic disease, and next to CM, and eventually to death. Combined exposure to five air pollutants were related with greater susceptibility of CM and all-cause mortality in a dose-dependent style and is related with the progression of CM and with all-cause mortality.https://doi.org/10.1038/s41598-024-77886-6Combined exposureMultistate modelGenetic susceptibilityProspective studyPublic healthAll-cause mortality |
| spellingShingle | Liang Xia Shan Zhou Liyuan Han Weifeng Sun Hongpeng Sun Joint association of air pollutants on cardiometabolic multimorbidity Scientific Reports Combined exposure Multistate model Genetic susceptibility Prospective study Public health All-cause mortality |
| title | Joint association of air pollutants on cardiometabolic multimorbidity |
| title_full | Joint association of air pollutants on cardiometabolic multimorbidity |
| title_fullStr | Joint association of air pollutants on cardiometabolic multimorbidity |
| title_full_unstemmed | Joint association of air pollutants on cardiometabolic multimorbidity |
| title_short | Joint association of air pollutants on cardiometabolic multimorbidity |
| title_sort | joint association of air pollutants on cardiometabolic multimorbidity |
| topic | Combined exposure Multistate model Genetic susceptibility Prospective study Public health All-cause mortality |
| url | https://doi.org/10.1038/s41598-024-77886-6 |
| work_keys_str_mv | AT liangxia jointassociationofairpollutantsoncardiometabolicmultimorbidity AT shanzhou jointassociationofairpollutantsoncardiometabolicmultimorbidity AT liyuanhan jointassociationofairpollutantsoncardiometabolicmultimorbidity AT weifengsun jointassociationofairpollutantsoncardiometabolicmultimorbidity AT hongpengsun jointassociationofairpollutantsoncardiometabolicmultimorbidity |