The impact of hyperventilation on brain alpha activity: An EEG study
Hyperventilation (HV) is a major physiological risk factor in environments like high altitudes or hypoxic conditions, causing a range of physiological changes that can potentially impair cognitive functions. As an important bridge connecting brain physiological states and cognitive functions, the va...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025001558 |
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| author | Xiaodong Yang Fugui Qi Chunhong Li Kaixin Liu Hao Yu Yi Han Ying Chen Yu Sun Chuantao Li |
| author_facet | Xiaodong Yang Fugui Qi Chunhong Li Kaixin Liu Hao Yu Yi Han Ying Chen Yu Sun Chuantao Li |
| author_sort | Xiaodong Yang |
| collection | DOAJ |
| description | Hyperventilation (HV) is a major physiological risk factor in environments like high altitudes or hypoxic conditions, causing a range of physiological changes that can potentially impair cognitive functions. As an important bridge connecting brain physiological states and cognitive functions, the variation of alpha activity under the effect of HV has not been fully explored. To this end, this work aims to reveal the changes in EEG alpha activity induced by HV in terms of power spectrum and functional connectivity (FC). EEG data were recorded from 305 healthy young male subjects when they were under three stages: Pre-HV, HV, and Post-HV. Then, EEG power spectrum was estimated and adjusted by removing the aperiodic components. The alpha peak frequency (APF) and adjusted alpha peak frequency (aAPF) were both slowed from Pre-HV to HV and recovered in Post-HV, which revealed a U-shaped trend. Both the alpha peak power (AP) and adjusted alpha peak power (aAP) decreased during HV. FC was assessed via the weighted Phase Lag Index (wPLI), which exhibited a HV-related decrease followed by an increase in Post-HV, with a rightward lateralization shift. In summary, both the power spectrum and FC metrics showed a U-shaped tendency, suggesting a negative impact of HV on alpha activity. Our findings provide some of the first quantitative insights into the effects of HV on alpha activity, further confirming the regulatory patterns of HV on neural activity. |
| format | Article |
| id | doaj-art-c8b6c8a26eb64960ab75776ed77bbb99 |
| institution | OA Journals |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-c8b6c8a26eb64960ab75776ed77bbb992025-08-20T02:29:34ZengElsevierBrain Research Bulletin1873-27472025-06-0122511134310.1016/j.brainresbull.2025.111343The impact of hyperventilation on brain alpha activity: An EEG studyXiaodong Yang0Fugui Qi1Chunhong Li2Kaixin Liu3Hao Yu4Yi Han5Ying Chen6Yu Sun7Chuantao Li8School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China; Naval Medical Center, Naval Medical University, Shanghai 200433, ChinaSchool of Biomedical Engineering, Fourth Military Medical University, 710032, ChinaNaval Medical Center, Naval Medical University, Shanghai 200433, ChinaNaval Medical Center, Naval Medical University, Shanghai 200433, ChinaNaval Medical Center, Naval Medical University, Shanghai 200433, ChinaNaval Medical Center, Naval Medical University, Shanghai 200433, ChinaNaval Medical Center, Naval Medical University, Shanghai 200433, ChinaDepartment of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, ChinaNaval Medical Center, Naval Medical University, Shanghai 200433, China; Corresponding author.Hyperventilation (HV) is a major physiological risk factor in environments like high altitudes or hypoxic conditions, causing a range of physiological changes that can potentially impair cognitive functions. As an important bridge connecting brain physiological states and cognitive functions, the variation of alpha activity under the effect of HV has not been fully explored. To this end, this work aims to reveal the changes in EEG alpha activity induced by HV in terms of power spectrum and functional connectivity (FC). EEG data were recorded from 305 healthy young male subjects when they were under three stages: Pre-HV, HV, and Post-HV. Then, EEG power spectrum was estimated and adjusted by removing the aperiodic components. The alpha peak frequency (APF) and adjusted alpha peak frequency (aAPF) were both slowed from Pre-HV to HV and recovered in Post-HV, which revealed a U-shaped trend. Both the alpha peak power (AP) and adjusted alpha peak power (aAP) decreased during HV. FC was assessed via the weighted Phase Lag Index (wPLI), which exhibited a HV-related decrease followed by an increase in Post-HV, with a rightward lateralization shift. In summary, both the power spectrum and FC metrics showed a U-shaped tendency, suggesting a negative impact of HV on alpha activity. Our findings provide some of the first quantitative insights into the effects of HV on alpha activity, further confirming the regulatory patterns of HV on neural activity.http://www.sciencedirect.com/science/article/pii/S0361923025001558Hyperventilation (HV)EEGPower spectrumAperiodic activityWeighted Phase Lag Index (wPLI) |
| spellingShingle | Xiaodong Yang Fugui Qi Chunhong Li Kaixin Liu Hao Yu Yi Han Ying Chen Yu Sun Chuantao Li The impact of hyperventilation on brain alpha activity: An EEG study Brain Research Bulletin Hyperventilation (HV) EEG Power spectrum Aperiodic activity Weighted Phase Lag Index (wPLI) |
| title | The impact of hyperventilation on brain alpha activity: An EEG study |
| title_full | The impact of hyperventilation on brain alpha activity: An EEG study |
| title_fullStr | The impact of hyperventilation on brain alpha activity: An EEG study |
| title_full_unstemmed | The impact of hyperventilation on brain alpha activity: An EEG study |
| title_short | The impact of hyperventilation on brain alpha activity: An EEG study |
| title_sort | impact of hyperventilation on brain alpha activity an eeg study |
| topic | Hyperventilation (HV) EEG Power spectrum Aperiodic activity Weighted Phase Lag Index (wPLI) |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025001558 |
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