The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease
Association of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of ex...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2004-06-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3624 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849242614220455936 |
|---|---|
| author | G. N. Seitova Ye. B. Bukreeva S. V. Buykin O. Yu. Bychkova Ye. A. Dementyeva S. V. Nesterovich V. P. Puzyryov |
| author_facet | G. N. Seitova Ye. B. Bukreeva S. V. Buykin O. Yu. Bychkova Ye. A. Dementyeva S. V. Nesterovich V. P. Puzyryov |
| author_sort | G. N. Seitova |
| collection | DOAJ |
| description | Association of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of expected in patient groups as well as in control groups at Hardy-Vainberg equilibrium. Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). Differences in genotype distribution at patients and control group have been found for Tatars due to heterosive carrier (AG) prevalence at patients (p < 0,05). The obtained data allow to conclude the presence of association of –308G/A-polymorphism of TNF gene with the COPD development at Siberian Tatars. |
| format | Article |
| id | doaj-art-c8b2c08a03744a7e990b73a5dea492b9 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2004-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-c8b2c08a03744a7e990b73a5dea492b92025-08-20T03:59:47ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842004-06-0132293410.20538/1682-0363-2004-2-29-342266The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary diseaseG. N. Seitova0Ye. B. Bukreeva1S. V. Buykin2O. Yu. Bychkova3Ye. A. Dementyeva4S. V. Nesterovich5V. P. Puzyryov6Siberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityResearch Institute of Medical GeneticsSiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical University; Research Institute of Medical GeneticsAssociation of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of expected in patient groups as well as in control groups at Hardy-Vainberg equilibrium. Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). Differences in genotype distribution at patients and control group have been found for Tatars due to heterosive carrier (AG) prevalence at patients (p < 0,05). The obtained data allow to conclude the presence of association of –308G/A-polymorphism of TNF gene with the COPD development at Siberian Tatars.https://bulletin.ssmu.ru/jour/article/view/3624chronic obstructive pulmonary diseasetnf geneα-tumor necrosis factor–308g/a-polymorphism |
| spellingShingle | G. N. Seitova Ye. B. Bukreeva S. V. Buykin O. Yu. Bychkova Ye. A. Dementyeva S. V. Nesterovich V. P. Puzyryov The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease Бюллетень сибирской медицины chronic obstructive pulmonary disease tnf gene α-tumor necrosis factor –308g/a-polymorphism |
| title | The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease |
| title_full | The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease |
| title_fullStr | The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease |
| title_full_unstemmed | The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease |
| title_short | The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease |
| title_sort | role of polymorphism in tnf gene promotive area in the development of chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease tnf gene α-tumor necrosis factor –308g/a-polymorphism |
| url | https://bulletin.ssmu.ru/jour/article/view/3624 |
| work_keys_str_mv | AT gnseitova theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT yebbukreeva theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT svbuykin theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT oyubychkova theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT yeadementyeva theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT svnesterovich theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT vppuzyryov theroleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT gnseitova roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT yebbukreeva roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT svbuykin roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT oyubychkova roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT yeadementyeva roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT svnesterovich roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease AT vppuzyryov roleofpolymorphismintnfgenepromotiveareainthedevelopmentofchronicobstructivepulmonarydisease |