Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis
Abstract Intraluminal prosthetic graft thrombus (IPT) has been described in case of endovascular aortic pathology repair. This study aimed to assess hemodynamic indicators associated with various anatomical morphologies following endovascular aortic repair (EVAR), aiming to offer further references...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-83148-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850034982710411264 |
|---|---|
| author | Yuansu Zhang Deyin Zhao Xiaomao Si Xiaoxing Yue Jinhui Chen Yongming Lu Peng Qiu Xinwu Lu Xinrui Yang |
| author_facet | Yuansu Zhang Deyin Zhao Xiaomao Si Xiaoxing Yue Jinhui Chen Yongming Lu Peng Qiu Xinwu Lu Xinrui Yang |
| author_sort | Yuansu Zhang |
| collection | DOAJ |
| description | Abstract Intraluminal prosthetic graft thrombus (IPT) has been described in case of endovascular aortic pathology repair. This study aimed to assess hemodynamic indicators associated with various anatomical morphologies following endovascular aortic repair (EVAR), aiming to offer further references for the choice of clinical therapy. Six model models (normal, iliac compression, aortic compression, aortoiliac compression, iliac distortion, and long-leg stent) were established based on common anatomical morphologies following EVAR. Hemodynamic indicators, such as flow velocity, time-average wall shear stress (TAWSS), oscillatory shear stress index (OSI), and relative residence time (RRT), were captured using computational fluid dynamics (CFD), and the differences between the six models were examined. The peak blood flow velocity at the compressed side iliac artery and the uncompressed side iliac artery corresponding to the aortoiliac artery compression model and the aortic compression model decreased by 30.63% to 48.62%, compared with that in the normal model. Compared with that in the normal model, the peak blood flow velocity at the aorta and the distorted side iliac artery in the iliac distortion model decreased by 7.89% and 41.13%, respectively. The length of the iliac artery stent has little effect on the blood flow velocity. The TAWSS at Iliac grafts showed varying degrees of decline in the other three compression models, particularly in the aortic compression model compared to the normal model. The TAWSS increases at the corner of the artery showing distortion but exhibited a significant decrease toward the distal end of the corner. The areas with higher OSI, and longer RRT were concentrated in the aortoiliac compression model and the iliac distortion model. We found that endograft compression and distortion may be risk factors for IPT. Moreover, the influence of longer stents on the hemodynamics inside stent-grafts is negligible. However, future real-world studies should be conducted to test and verify this speculation. |
| format | Article |
| id | doaj-art-c8acfb8078234c4dbb4725e8fe0af263 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c8acfb8078234c4dbb4725e8fe0af2632025-08-20T02:57:39ZengNature PortfolioScientific Reports2045-23222024-12-0114111410.1038/s41598-024-83148-2Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysisYuansu Zhang0Deyin Zhao1Xiaomao Si2Xiaoxing Yue3Jinhui Chen4Yongming Lu5Peng Qiu6Xinwu Lu7Xinrui Yang8Department of Vascular Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversitySecond ward of General Surgery, Suzhou Hospital of Anhui Medical UniversityDepartment of General Surgery, The TCM Hospital of Nanling County Wuhu CityDepartment of Vascular Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityDepartment of Vascular Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityDepartment of Vascular Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract Intraluminal prosthetic graft thrombus (IPT) has been described in case of endovascular aortic pathology repair. This study aimed to assess hemodynamic indicators associated with various anatomical morphologies following endovascular aortic repair (EVAR), aiming to offer further references for the choice of clinical therapy. Six model models (normal, iliac compression, aortic compression, aortoiliac compression, iliac distortion, and long-leg stent) were established based on common anatomical morphologies following EVAR. Hemodynamic indicators, such as flow velocity, time-average wall shear stress (TAWSS), oscillatory shear stress index (OSI), and relative residence time (RRT), were captured using computational fluid dynamics (CFD), and the differences between the six models were examined. The peak blood flow velocity at the compressed side iliac artery and the uncompressed side iliac artery corresponding to the aortoiliac artery compression model and the aortic compression model decreased by 30.63% to 48.62%, compared with that in the normal model. Compared with that in the normal model, the peak blood flow velocity at the aorta and the distorted side iliac artery in the iliac distortion model decreased by 7.89% and 41.13%, respectively. The length of the iliac artery stent has little effect on the blood flow velocity. The TAWSS at Iliac grafts showed varying degrees of decline in the other three compression models, particularly in the aortic compression model compared to the normal model. The TAWSS increases at the corner of the artery showing distortion but exhibited a significant decrease toward the distal end of the corner. The areas with higher OSI, and longer RRT were concentrated in the aortoiliac compression model and the iliac distortion model. We found that endograft compression and distortion may be risk factors for IPT. Moreover, the influence of longer stents on the hemodynamics inside stent-grafts is negligible. However, future real-world studies should be conducted to test and verify this speculation.https://doi.org/10.1038/s41598-024-83148-2Abdominal aortic aneurysmEndovascular aneurysm repairHemodynamic indicatorComputational fluid dynamicsIntraluminal prosthetic graft thrombus |
| spellingShingle | Yuansu Zhang Deyin Zhao Xiaomao Si Xiaoxing Yue Jinhui Chen Yongming Lu Peng Qiu Xinwu Lu Xinrui Yang Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis Scientific Reports Abdominal aortic aneurysm Endovascular aneurysm repair Hemodynamic indicator Computational fluid dynamics Intraluminal prosthetic graft thrombus |
| title | Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis |
| title_full | Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis |
| title_fullStr | Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis |
| title_full_unstemmed | Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis |
| title_short | Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis |
| title_sort | endograft specific hemodynamics after endovascular aneurysm repair a cfd analysis |
| topic | Abdominal aortic aneurysm Endovascular aneurysm repair Hemodynamic indicator Computational fluid dynamics Intraluminal prosthetic graft thrombus |
| url | https://doi.org/10.1038/s41598-024-83148-2 |
| work_keys_str_mv | AT yuansuzhang endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT deyinzhao endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT xiaomaosi endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT xiaoxingyue endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT jinhuichen endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT yongminglu endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT pengqiu endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT xinwulu endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis AT xinruiyang endograftspecifichemodynamicsafterendovascularaneurysmrepairacfdanalysis |